Document Detail


Clinical features and treatment approaches in cystic fibrosis with pseudo-Bartter syndrome.
MedLine Citation:
PMID:  15949200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Infants with cystic fibrosis (CF) are prone to develop episodes of hyponatraemic, hypochloraemic dehydration with metabolic alkalosis, which are biochemical hallmarks of the pseudo-Bartter syndrome (PB). METHOD: We reviewed the clinical and laboratory features and treatment approaches of 29 children with CF and PB who were under follow-up in our institution from May 1992 to November 2003. RESULTS: Of 241 patients with CF, PB was detected in 29 (12%) with a median age of 4 months at the time of the first attack. Most patients experienced vomiting, loss of appetite and dehydration during episodes of PB. All patients were managed with intravenous fluids and sodium chloride solutions. During follow-up, 12/29 cases required hospital admission for recurrent PB attacks. The oldest age at the time of the last attack was 48 months. CONCLUSIONS: CF should be considered in the differential diagnosis of metabolic alkalosis in young children. Vomiting and loss of appetite are important warning signs of possible PB in CF patients, particularly before 4 years of age. To prevent serious complications, it is crucial that parents and physicians recognise PB as early as possible.
Authors:
Ebru Yalçin; Nural Kiper; Deniz Doğru; Uğur Ozçelik; Ayşe Tana Aslan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  25     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-10-25     Revised Date:  2006-07-25    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. ebruy@hacettepe.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bartter Syndrome / complications*,  therapy*
Child
Child, Preschool
Cystic Fibrosis / complications*,  therapy*
Diagnosis, Differential
Eating Disorders / etiology
Female
Humans
Infant
Male
Rehydration Solutions / administration & dosage
Retrospective Studies
Sodium Chloride / administration & dosage
Treatment Outcome
Vomiting / etiology
Chemical
Reg. No./Substance:
0/Rehydration Solutions; 7647-14-5/Sodium Chloride
Comments/Corrections
Comment In:
Ann Trop Paediatr. 2006 Jun;26(2):155   [PMID:  16709338 ]

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