| Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients. | |
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MedLine Citation:
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PMID: 22744391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients. METHODS: Clinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B). RESULTS: Group A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P<0.001), less active (CAS 1.50 vs 2.26, P=0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P=0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P=0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P<0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P=0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P<0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P=0.337). CONCLUSIONS: Patients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients. |
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Authors:
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S Y Jang; S Y Lee; E J Lee; J S Yoon |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-06-29 |
Journal Detail:
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Title: Eye (London, England) Volume: 26 ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-17 Completed Date: 2013-01-17 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1263-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Euthyroid Sick Syndromes / diagnosis*, immunology Eyelid Diseases / diagnosis, immunology Female Graves Ophthalmopathy / diagnosis*, immunology Humans Hyperthyroidism / diagnosis, immunology Immunoglobulins, Thyroid-Stimulating / blood Korea Male Optic Nerve Diseases / diagnosis, immunology Receptors, Thyrotropin / immunology Retrospective Studies Thyroxine / blood Tomography, X-Ray Computed Triiodothyronine / blood Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Thyroid-Stimulating; 0/Receptors, Thyrotropin; 0/thyrotropin-binding inhibitory immunoglobulin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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