| Clinical features and therapy of acute thallium poisoning. | |
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MedLine Citation:
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PMID: 3271337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe acute thallium poisoning in a young man is described. He presented with transient loss of consciousness and paraesthesiae of finger tips and lips, with a blood thallium concentration of 5750 micrograms/l (levels above 200 micrograms/l are toxic). He rapidly lost limb sensation and power and later required temporary mechanical ventilation and nasogastric feeding. The neurological sequelae one year afterwards are a flaccid paraparesis, cerebellar ataxia and mental impairment. Immediate cardiovascular complications included hypertension, sinus tachycardia, ECG abnormalities and an episode of ventricular fibrillation. We were able to assess the relative merits of different methods advocated for enhancing thallium excretion. Oral Prussian blue, forced diuresis and haemodialysis were found to be the most effective: 2000 mg of thallium were eliminated over 20 days, 820 mg over 46 days and 225 mg over 25 days respectively by these methods. Haemofiltration was ineffective. Diethyldithiocarbamate, a chelating agent, brought about a rise in serum thallium concentration accompanied by clinical deterioration and its use should be abandoned. |
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Authors:
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A P Wainwright; W J Kox; I M House; J A Henry; R Heaton; W A Seed |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Quarterly journal of medicine Volume: 69 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1990-03-01 Completed Date: 1990-03-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 939-44 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Charing Cross Hospital, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Diuresis Humans Male Neural Conduction Renal Dialysis Thallium / analysis, poisoning* |
| Chemical | |
Reg. No./Substance:
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7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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