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Clinical features, prognostic factors, and their relationship with antiplatelet antibodies in children with immune thrombocytopenia.
MedLine Citation:
PMID:  22215094     Owner:  NLM     Status:  In-Data-Review    
We investigated and evaluated the demographics, clinical and laboratory features, treatment responses, and disease duration of 25 children with immune thrombocytopenia (ITP) eligible for detection of antiplatelet antibodies. We found that patients without antecedent of preceding infection (API) were more likely to have anti-GPIa/IIa than those with API (42.9% vs. 5.5%, P=0.048). Age groups of <2 years and 2 to 10 years were more likely to show response (R) or complete response (CR) to given treatments, whereas none of the patients whose onset age >10 years showed R or CR to given treatments (88.9% and 100% vs 0%, P=0.001). The percentage of newly diagnosed ITP was higher in age groups of <2 years (100%) and in 2 to 10 years (90%) than the age group of >10 years (16.7%, P=0.001). Patients without API (71.4%) were more likely to develop chronic ITP than those with API (5.6%, P=0.002). In conclusion, younger age was a favorable prognostic factor, especially in patients <2 years of age with respect to treatment responses and disease duration. In addition, API was associated with a short disease course as well as absence of anti-GPIa/IIa.
Wan-Ling Ho; Chin-Cheng Lee; Chiung-Ju Chen; Meng-Yao Lu; Fu-Chang Hu; Shiann-Tarng Jou; Dong-Tsamn Lin; Kai-Hsin Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  34     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-12     Citation Subset:  IM    
*Department of Pediatrics §Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital ‡Division of Hematology/Oncology, Department of Pediatrics, National Taiwan University Hospital ∥International Harvard Statistical Consulting Company, Taipei †School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
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