Document Detail


Clinical features and prognosis in adult-onset Still's disease: a study of 104 cases.
MedLine Citation:
PMID:  20549276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study is to evaluate the clinical features and prognosis of adult-onset Still's disease (AOSD). One hundred and four AOSD patients who were analyzed retrospectively were enrolled in this study. Medical charts were systematically reviewed for: demographic data, clinical features, laboratory findings, treatments, and outcomes. The major clinical features were: spiking fever 100%, evanescent maculopapular rash 95%, polyarthralgia 90%, sore throat 78%, lymphadenopathy 66%, hepatosplenomegaly 57%, hydrohymenitis 30%, neutrophilia 98%, liver disfunction 62%, increased erythrocyte sedimentation rate (ESR) 96%, and hyperferritinaemia 99%. Reactive hyperplasia was shown in all patients who underwent lymph node biopsy. Ninety-five percent and 63% of the patients were treated with glucocorticoid and immune suppressant, respectively. Those with prednisone or its equivalent dosage of > or =0.8 mg/kg/d achieved quicker remission and less relapse. Persistent fever, evanescent rash, arthritis, and sore throat were the most prevalent symptoms in patients with AOSD, with laboratory findings of leukocytosis, elevated liver enzymes, elevated ESR and serum ferritin. Glucocorticoid and immune suppressive drugs are effective for AOSD; however, the relapsing rate is relatively high. High levels of white blood cells, serum ferritin and ESR, as well as glucocorticoid dosage were related to relapse.
Authors:
Xiao-Dan Kong; Dong Xu; Wen Zhang; Yan Zhao; Xiaofeng Zeng; Fengchun Zhang
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Publication Detail:
Type:  Journal Article     Date:  2010-06-14
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1015-9     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, The second affiliated hospital of Dalian Medical University, Dalian, 116027, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arthritis / physiopathology
Exanthema / physiopathology
Female
Fever / physiopathology
Glucocorticoids / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Male
Middle Aged
Pharyngitis / physiopathology
Prognosis
Retrospective Studies
Still's Disease, Adult-Onset / diagnosis*,  drug therapy,  physiopathology*
Young Adult
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents

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