Document Detail


Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations.
MedLine Citation:
PMID:  19151788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diffuse large B-cell lymphoma (DLBCL) having both t(14;18) and 8q24 translocations is rare. We evaluated the clinical characteristics and prognoses of patients with DLBCL carrying both t(14;18) and 8q24 translocations. A total of 1972 patients with non-Hodgkin's lymphoma were treated in the Adult Lymphoma Treatment Study Group (ALTSG) from 1998 to 2007. Nineteen cases of de novo DLBCL with the dual translocation were identified. The dual translocation was observed in 19 of 394 patients with DLBCL (10 males and 9 females, with a median age of 61 years). The dual translocation was observed significantly more frequently among patients with high lactate dehydrogenase levels, B symptoms, bone marrow involvement and advanced stage. Immunophenotyping was performed and showed DLBCL with a germinal center type in the majority of cases. Progression-free survival and overall survival rates were significantly lower in patients with the dual translocation than in those with other translocation. DLBCL patients with concurrent t(14;18) and 8q24 translocations have very poor prognosis. Even if patients had a complete response to chemotherapy, they subsequently suffered early relapse. In this study, only a few patients received rituximab, and its usefulness could not be assessed. Future studies with larger numbers of patients are required.
Authors:
N Niitsu; M Okamoto; I Miura; M Hirano
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Publication Detail:
Type:  Journal Article     Date:  2009-01-08
Journal Detail:
Title:  Leukemia     Volume:  23     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-05-04     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  777-83     Citation Subset:  IM    
Affiliation:
Department of Hematology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Saitama, Japan. nniitsu@saitama-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / pathology
Bone Marrow / pathology
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 18*
Chromosomes, Human, Pair 8*
Disease-Free Survival
Female
Humans
L-Lactate Dehydrogenase
Lymphoma, Large B-Cell, Diffuse / diagnosis,  genetics*,  mortality
Lymphoma, Non-Hodgkin
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins c-myc / genetics*
Survival Rate
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/MYC protein, human; 0/Proto-Oncogene Proteins c-myc; EC 1.1.1.27/L-Lactate Dehydrogenase

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