Document Detail

Clinical features of patients with multiple sclerosis from a survey in Shanghai, China.
MedLine Citation:
PMID:  18424476     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe clinical features of patients with multiple sclerosis (MS) in Shanghai, China. METHODS: Prevalent patients with MS were identified and investigated by a network of physicians in 11 districts of Shanghai during the period from 1 September 2004 to 31 August 2005. Admission registries of each hospital in the study area were checked systematically for patients with a diagnosis of MS, neuromyelitis optica or other demyelinating disorders. All patients with collected information were evaluated by four senior neurologists according to the McDonald criteria. RESULTS: There were 249 (146 female and 103 male) patients with a confirmed MS diagnosis, at a female-to-male ratio of 1.4. The mean age at onset of MS was 37.4 years for the 249 patients with MS and, on the prevalence day, 42.7 years. The most frequent location of clinical MS lesions in the central nervous system was the spinal cord (61%), followed by the cerebrum (55%) and optic nerves (41%). Nearly all (96%) of the patients with MS had been examined by magnetic resonance imaging, and 226 (94%) patients of those examined were suggestive of MS. No family history of MS was found in any of the patients. Most (86%) of the patients had no or mild disability on the prevalence day (31 December 2004). Almost all (96%) patients with MS had been treated with corticosteroids. CONCLUSION: Clinical features of patients with MS are described based on the information from the largest case series reported among Chinese. Comparisons and discussions are made with findings from the other populations.
Q Cheng; L Miao; J Zhang; Y T Guan; Z G Liu; X Wang; X J Sun; Z X Zhao; Y J Song; X Y Ding; Z I Guo; X J Cheng; S D Chen; G X Jiang; S Fredrikson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  14     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
Department of Neurology, Ruijin Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China.
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MeSH Terms
Asian Continental Ancestry Group / statistics & numerical data*
China / epidemiology
Data Collection
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis, Chronic Progressive / ethnology*,  pathology
Multiple Sclerosis, Relapsing-Remitting / ethnology*,  pathology
Neuromyelitis Optica / epidemiology
Severity of Illness Index

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