Document Detail


Clinical features and outcome of surgery in 30 patients with acromegaly.
MedLine Citation:
PMID:  15366797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the surgical outcome of hypophysectomy in acromegalic patients, differences in response to surgery in micro and macroadenoma and the development of associated hormonal deficiency after surgery. METHODS: Retrospective analysis of charts of acromegalic patients who were operated upon at Aga Khan University Hospital, Karachi, was done. Information regarding presentation, laboratory data, radiological assessment, details of surgery and postoperative outcome was recorded. Surgical outcome was classified depending on the degree of disease control after surgery as biochemical cure, remission and treatment failure. RESULTS: Out of 30 patients, eighteen (60%) were males and 12 (40%) females with mean age at the time of diagnosis 35.6+/-10.4 years. The mean duration of symptoms was 3.2+/-2.4 years. Twenty-five patients had macroadenoma and five had microadenoma. Preoperative mean GH level was 42.4 ng/ml with range of 2.5 to 534 ng/ml. Following surgery, 13 had biochemical cure, 4 were in remission and 13 failed to respond. The outcome in microadenoma was better than in macroadenoma i.e. 100% vs. 32%. Preoperatively four patients had panhypopituitarism with additional six patients (20%) developing hypopituitarism postoperatively. CONCLUSION: Our study showed that acromegaly was seen at a much earlier age, outcome of surgery was comparable to other international studies and postoperative panhypopituitarism was seen in significant number of patients. The outcome in microadenoma was better than in macroadenoma but the number of patients seen with microadenoma was small.
Authors:
A Chandna; N Islam; A Jabbar; L Zuberi; N Haque
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  54     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-09-15     Completed Date:  2004-10-21     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Affiliation:
Endocrinology Section, Department of Medicine, Aga Khan University Hospital, Karachi.
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MeSH Terms
Descriptor/Qualifier:
Acromegaly / complications,  metabolism,  surgery*
Adenoma / complications
Adolescent
Adult
Age Factors
Aged
Human Growth Hormone / secretion
Humans
Hypopituitarism / complications
Magnetic Resonance Imaging
Middle Aged
Postoperative Care
Postoperative Complications
Preoperative Care
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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