Document Detail

Clinical features of neocortical temporal lobe epilepsy.
MedLine Citation:
PMID:  8957013     Owner:  NLM     Status:  MEDLINE    
Few studies have examined the clinical features of neocortical temporal lobe epilepsy (NTLE) in carefully selected patients. We reviewed records from 21 patients with NTLE, defined by intracranial electroencephalogram (EEG), who have been seizure free for 1 year or more following temporal lobectomy. The mean age of onset at the time of first seizure was 14 years (range, 1-41 years). Febrile seizures were reported in only 2 patients (9.5%). In contrast to prior mesial temporal lobe epilepsy (MTLE) studies, seizure-free intervals between the initial cerebral insult or first seizure and habitual seizures were uncommon. Possible or known risk factors for epilepsy were reported in 13 of 21 patients (62%). Fifteen (71%) patients reported auras, with experiential phenomena being the most common type. Magnetic resonance imaging was normal or nonspecific in 15 patients, revealed mild hippocampal atrophy in 2, tumors in 2, and heterotopic gray matter and hippocampal atrophy in 1, and cortical dysgenesis in 1. Neuropsychological testing showed deficits consistent with the seizure focus in 13 patients (62%), and Wada test showed ipsilateral memory deficits in 10 (48%). The most common behavioral manifestation was a motionless stare at ictal onset (48%). In contrast to prior studies of MTLE, only 1 NTLE patient had frequent independent, contralateral temporal lobe epileptiform spikes on scalp EEG.
S V Pacia; O Devinsky; K Perrine; L Ravdin; D Luciano; B Vazquez; W K Doyle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  40     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  724-30     Citation Subset:  IM    
Department of Neurology, NYU/HJD Comprehensive Epilepsy Center, Hospital for Joint Diseases, New York, NY 10003, USA.
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MeSH Terms
Age of Onset
Brain / pathology*
Disease-Free Survival
Epilepsy, Temporal Lobe / pathology,  physiopathology*,  surgery*
Magnetic Resonance Imaging
Neuropsychological Tests
Retrospective Studies
Risk Factors

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