Document Detail


Clinical features and molecular alterations of traditional serrated adenoma in sporadic colorectal carcinogenesis.
MedLine Citation:
PMID:  21615873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare clinical features and molecular alterations between traditional serrated adenomas (TSA) & serrated carcinomas (SCa) and traditional adenomas (TA) & carcinomas (Ca) of the colorectum and to verify a traditional serrated pathway of sporadic colorectal carcinogenesis.
METHODS: One thousand two hundred slides of colorectal polyps obtained from 1160 patients were collected and reviewed to define TSA and clinical and pathological features were analyzed and compared with TA. DNA was extracted from specimens of TSA, TA, SCa and Ca, v-raf murine sarcoma viral oncogene homolog B (BRAF) V600E mutation and microsatellite instability (MSI) (assay for BAT25 and BAT26) were analyzed.
RESULTS: Overall 29 TSA were confirmed (2.5%), and there was an age difference between patients with TSA and TA (56.0 vs 62.7, P<0.05). Compared with TA, TSA was located more often in the rectosigmoid colon (TSA 62.1% vs TA 35.2%, P<0.05), but occurred less in the descending colon (TSA 0% vs TA 25.35%, P=0.0068). No difference was found in terms of gender and the size or pedicles of polyps (P>0.05). The BRAF V600E mutation was detected in 36.3% of SCa and 26.7% of TSA patients, but it was not detected in TA and Ca patients; MSI-H was noticed in 23% of SCa, 33.3% of TSA, 5.3% of Ca and 0% of TA patients, respectively (P<0.05).
CONCLUSION: There might be a traditional serrated pathway of sporadic colorectal carcinogenesis that is different from the conventional adenoma to carcinoma carcinogenesis pathway in the colorectum.
Authors:
Ying Han; Zhi Yong Zhou
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  12     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-09-30     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Gastroenterology, People's Liberation Army, The Military General Hospital of Beijing, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / genetics*,  pathology*
Adult
Aged
Cell Transformation, Neoplastic / genetics*,  pathology*
Colorectal Neoplasms / genetics*,  pathology*
DNA, Neoplasm / genetics
Female
Humans
Male
Microsatellite Instability
Middle Aged
Mutation / genetics
Proto-Oncogene Proteins B-raf / genetics
Retrospective Studies
Signal Transduction
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf

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