| Clinical features and long-term treatment with pimozide in 65 patients with Gilles de la Tourette's syndrome. | |
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MedLine Citation:
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PMID: 3462344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the last seven years 65 patients with Gilles de la Tourette's syndrome have been treated. Pimozide was used as the preferred drug because of our experience of treating other hyperkinesias which indicated fewer side-effects than with haloperidol. Of the 65 patients with Gilles de la Tourette's syndrome, 59 were treated with pimozide alone or in combination with tetrabenazine or clonidine. The dose ranges of pimozide were 0.5-9 mg per day. Eighty-one percent experienced a good clinical response without side-effects. The side-effects seen in our patients were sedation, gain in weight, depression, pseudoparkinsonism and akathisia; acute dystonic reactions, blurred vision, slurred speech and xerostomia did not occur. No cases of tardive dyskinesia were seen. |
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Authors:
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L Regeur; B Pakkenberg; R Fog; H Pakkenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 49 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-10-03 Completed Date: 1986-10-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 791-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Clonidine / administration & dosage Drug Therapy, Combination Electroencephalography Female Humans Male Middle Aged Pimozide / administration & dosage, adverse effects, therapeutic use* Tetrabenazine / administration & dosage Tomography, X-Ray Computed Tourette Syndrome / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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2062-78-4/Pimozide; 4205-90-7/Clonidine; 58-46-8/Tetrabenazine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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