Document Detail


Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy.
MedLine Citation:
PMID:  19781364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypogammaglobulinemia is common in infant humoral immunodeficiencies and has complicated causes and outcomes. We aimed to determine the clinical manifestations, immunological changes and outcomes of Shanghai infants with hypogammaglobulinemia. METHODS: Patients under 2 years old, having one or more warning signs of primary immunodeficiency disorders, serum immunoglobulin levels below the lower limit of reference range per age, and with normal numbers for lymphocyte subsets, were analyzed and followed up for 2 to 3 years. RESULTS: A total of 91 children (male-to-female ratio: 2.25: 1) participated in the study. Initial clinical presentation was recurrent upper respiratory tract infection (46%), invasive infection (3%), atopic disease (32%). IgA reduction (77%) was prevalent; 34% patients had more than one isotype reduced. During follow-up, 51 of 62 patients (82.25%) had immunoglobulins normalized at the age between 12 - 48 months; these were diagnosed as transient hypogammaglobulinemia of infancy (THI). Long-term follow-up may reveal a diagnosis for the remaining 11 infants with persistent lower immunoglobulin levels, who did not have antibody titers measured. Earlier onset was correlated with higher rates of normalization. More patients were diagnosed with isolated hypogammaglobulinemia in 2006 compared with the previous 4 years (2002 - 2005). CONCLUSIONS: The awareness of immunodeficiency among pediatricians has been greatly improved. Recurrent otitis media was not a major infection in our patients. THI is a relatively common condition associated with infant hypogammaglobulinemia. In the absence of specific antibody titers, the diagnosis of THI can be confirmed retrospectively with Ig levels normalized in follow-up visits. Therefore, long-term follow-up and frequent re-evaluation of these patients are necessary to distinguish them from true primary immunodeficiency.
Authors:
Ji-hong Qian; Jian-xing Zhu; Xiao-dong Zhu; Tong-xin Chen
Related Documents :
21262044 - Enhancing infant attachment security: an examination of treatment efficacy and differen...
8822284 - Enterovirus in sudden unexpected deaths in infants.
17699084 - Neonatal mortality in new zealand sea lions (phocarctos hookeri) at sandy bay, enderby ...
2181514 - Chlamydial infections.
9224184 - The effect of high altitude and other risk factors on birthweight: independent or inter...
19657114 - Outcome of congenital acute lymphoblastic leukemia treated on the interfant-99 protocol.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  122     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1877-83     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Agammaglobulinemia / epidemiology,  metabolism,  pathology*
Child
Child, Preschool
China / epidemiology
Female
Follow-Up Studies
Humans
Infant
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ultrasonic appearance of rhabdomyolysis in patients with crush injury in the Wenchuan earthquake.
Next Document:  Effect of topical application of terbinafine on fungal keratitis.