| Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients. | |
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MedLine Citation:
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PMID: 21354448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Alveolar echinococcosis (AE) is a rare disease in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis. METHODS: We present here 387 detailed AE cases diagnosed in France from 1982 to 2007 actively identified by a retrospective survey performed in 1997-1998 and prospectively thereafter. RESULTS: Male:female ratio was 1.03 and mean age 57.8 years at time of diagnosis. Among the 362 complete files (including 347 non dead-out and 15 dead-out lesions), 73% of the patients were symptomatic at first admittance. Among them, 83% presented with clinical patterns evocative either of a digestive or a hepatic disorder. Other symptomatic patients presented with erratic clinical pictures, generally due to metastasis or extra-hepatic location of the parasite. Except for a few patients with particularly severe AE who died shortly after the diagnosis, most patients were treated using benzimidazoles. Their mortality tends to merge with that of the general French population, matched by sex, age, and calendar year. This study also highlights an unexpectedly high frequency of blood-tied family cases (13% of patients submitted to a specific questionnaire). CONCLUSIONS: Even though the broad set of clinical features provoked by E. multilocularis makes AE a potential diagnostic trap for many physicians, our study revealed an improvement of its prognosis. However, as shown by our findings about the frequency of family cases, there is still a need for studies aimed at better describing this uncommon parasitic disease. |
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Authors:
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Martine Piarroux; Renaud Piarroux; Roch Giorgi; Jenny Knapp; Karine Bardonnet; Bertrand Sudre; Jérôme Watelet; Jérôme Dumortier; Alain Gérard; Jean Beytout; Armand Abergel; Georges Mantion; Dominique A Vuitton; Solange Bresson-Hadni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-25 |
Journal Detail:
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Title: Journal of hepatology Volume: 55 ISSN: 1600-0641 ISO Abbreviation: J. Hepatol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-19 Completed Date: 2012-03-06 Revised Date: 2012-08-24 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 1025-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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TheMA, UMR CNRS 6049, Université de Franche-Comté, 25030 Besançon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Animals Anthelmintics / therapeutic use Benzimidazoles / therapeutic use Echinococcosis, Hepatic / diagnosis*, epidemiology*, parasitology, therapy Echinococcus multilocularis* Female France / epidemiology Humans Incidence Liver Transplantation Male Middle Aged Prognosis Prospective Studies Questionnaires Retrospective Studies Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anthelmintics; 0/Benzimidazoles |
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