Document Detail


Clinical features, diagnostic approach, and therapeutic outcome in myasthenia gravis patients with thymectomy.
MedLine Citation:
PMID:  19537570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Thymectomy has been widely employed in the treatment of myasthenia gravis (MG). However, little data exist in Iran demonstrating the efficacy and morbidity of thymectomy. The aim of this study was to determine the clinical features, diagnostic approach, and therapeutic outcome in patients with MG who underwent thymectomy. METHODS: This historical cohort study was conducted in 3 university hospitals in Tehran. Preoperative and operative indices of 61 patients with MG who had been treated with thymectomy in these hospitals from September 2000 to July 2005 were reviewed. Among them, 20 patients were followed during one year after operation for determination of postoperative complications and one year mortality rate. RESULTS: The most common manifestations of MG were ptosis (77.0%) and upper limbs weakness (70.4%). CT scans of the thymus showed thymus enlargement, thymoma and thymus hyperplasia in 51.5% (22/43), 11.6% (5/43) and 2.32% (1/43) of patients, respectively. The postoperative complications were found in 13.1% of patients and one year mortality rate of thymectomy was 6.6%. CONCLUSION: Regarding to high one year mortality rate of thymectomy in patients of MG in this study, the assessment of the factors related to the mortality and outcome of patients who underwent thymectomy in Iran are necessary.
Authors:
Ali Yaghoobi Notash; Javad Salimi; Fariba Ramezanali; Mehrdad Sheikhvatan; Gholamreza Habibi
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Acta neurologica Taiwanica     Volume:  18     ISSN:  1028-768X     ISO Abbreviation:  Acta Neurol Taiwan     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815355     Medline TA:  Acta Neurol Taiwan     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Medical Sciences/University of Tehran, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Blepharoptosis / etiology,  physiopathology
Cohort Studies
Electromyography
Extremities / physiopathology
Female
Hospitals, University
Humans
Iran
Male
Middle Aged
Muscle Weakness / etiology,  physiopathology
Myasthenia Gravis / complications*,  diagnosis*,  pathology,  physiopathology,  surgery,  therapy
Postoperative Complications / epidemiology,  etiology
Prognosis
Retrospective Studies
Sex Factors
Thymectomy* / adverse effects,  methods
Thymoma / complications,  diagnosis*,  epidemiology,  surgery
Thymus Hyperplasia / complications,  diagnosis*,  epidemiology,  surgery
Thymus Neoplasms / complications,  diagnosis*,  physiopathology,  surgery
Tomography, X-Ray Computed
Treatment Outcome

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