Document Detail


Clinical features of chinese patients with Behçet's disease.
MedLine Citation:
PMID:  17692378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To characterize the clinical features of Behçet's disease in Chinese patients. DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Seven hundred seventy-five eyes of 437 patients with Behçet's disease initially examined from August, 1995, through June, 2006. METHODS: The history, demographic parameters, and clinical findings of all consecutive Behçet's patients referred to the uveitis study center of Sun Yat-sen University were reviewed. Laser flare-cell photometry (LFCM), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), ultrasound biomicroscopy (UBM), and B-scan ultrasonography were performed in certain cases. Most patients were treated by immunosuppressive agents combined with oral corticosteroids. MAIN OUTCOME MEASURES: Patient demographics, clinical presentation, and auxiliary examination findings. RESULTS: Four hundred thirty-seven patients were diagnosed with Behçet's disease. There were 319 male and 118 female patients. Panuveitis was the most common type of uveitis in both genders, although anterior uveitis was seen more frequently in females. Retinal vasculitis, vitreitis, and retinitis were the most common ocular manifestations in these patients. Cataract and macular edema were the most common complications. Oral aphthae were the most frequent extraocular manifestation, followed by dermatologic lesions, and genital ulcers. The results of FFA, OCT, B-scan ultrasonography, LFCM, and UBM generally were in accordance with or comparable with clinical observations. At the final visit, uveitis was well controlled in 86.2% of patients. However, 20.4% of eyes became legally blind despite aggressive treatment. Kaplan-Meier analysis estimated the risk of losing useful vision (0.05) at 5 and 10 years for males and females as 29% versus 6% and 65% versus 33%, respectively. CONCLUSIONS: Behçet's disease in Chinese patients mainly manifests as nongranulomatous uveitis frequently associated with oral aphthae and dermatologic lesions. Fundus fluorescein angiography, B-scan ultrasonography, LFCM, UBM, and OCT may provide much information about pathophysiologic hallmarks of Behçet's disease. A combination of corticosteroids with other immunosuppressive agents is effective for most patients with Behçet's disease. Males had a more severe course and were at higher risk for losing vision than females.
Authors:
Peizeng Yang; Wang Fang; Qianli Meng; Yalin Ren; Lin Xing; Aize Kijlstra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-10
Journal Detail:
Title:  Ophthalmology     Volume:  115     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-318.e4     Citation Subset:  IM    
Affiliation:
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. peizengy@126.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Asian Continental Ancestry Group / ethnology*
Behcet Syndrome / diagnosis*,  drug therapy,  ethnology*
Child
Child, Preschool
China / epidemiology
Drug Therapy, Combination
Female
Fluorescein Angiography
Follow-Up Studies
Glucocorticoids / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Male
Microscopy, Acoustic
Middle Aged
Photometry
Retrospective Studies
Tomography, Optical Coherence
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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