| Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness. | |
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MedLine Citation:
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PMID: 15949933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: We still do not know why some subjects with airway hyperresponsiveness (AHR) experience no respiratory symptoms. OBJECTIVES: Our aim was to compare pulmonary function, perception of bronchoconstriction, and airway inflammation in atopic subjects with mild recently diagnosed (<5 years, n=30) or longer-standing (5 years or more, n=30) symptomatic asthma in comparison with atopic subjects with asymptomatic AHR (n=27). METHODS: All subjects had measurements of expiratory flows, PC(20) methacholine, perception of breathlessness and induced sputum cell differential, eosinophil cationic protein and alpha(2)-macroglobulin levels. RESULTS: Compared with the other groups, PC(20) was significantly lower in longer-standing asthma and perception score for breathlessness at 20% fall in FEV(1) was lower in asymptomatic subjects. Markers of airway inflammation were similar in all groups. There were no significant correlations between sputum eosinophils, alpha(2)-macroglobulin and/or eosinophil cationic protein levels and FEV(1), FVC or PC(20) in either group. CONCLUSION: Subjects with mild asthma or asymptomatic AHR are similar in regard to induced sputum markers of airway inflammation. Although perception of bronchoconstriction was slightly lower in asymptomatic subjects, additional factors are probably involved to explain why they report no respiratory symptoms. Further studies are needed to determine why these last are asymptomatic. |
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Authors:
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Louis-Philippe Boulet; Philippe Prince; Hélène Turcotte; Catherine Lemière; Ronald Olivenstein; Catherine Laprise; Pierre Larivée; Paul Bégin; Michel Laviolette |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-09 |
Journal Detail:
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Title: Respiratory medicine Volume: 100 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-17 Completed Date: 2006-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 292-9 Citation Subset: IM |
Affiliation:
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Unité de Recherche en Pneumologie de l'Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, 2725 Ch. Ste-Foy, Québec, Canada. lpboulet@med.ulaval.ca |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asthma / pathology*, physiopathology Bronchial Hyperreactivity / pathology*, physiopathology Bronchial Provocation Tests Bronchitis / pathology* Female Forced Expiratory Volume / physiology Humans Male Middle Aged Sputum / cytology Vital Capacity / physiology |
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