Document Detail


Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study.
MedLine Citation:
PMID:  18253706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To clarify the clinical features of adult patients with acute leukemia (AL) with 11q23 abnormalities, we performed a retrospective analysis of data from 58 adult Japanese patients: 51 with acute myeloid leukemia (AML), and 7 with acute lymphoblastic leukemia (ALL). The incidences according to fusion partners in AML were: t(9;11), 31.3%; t(11;19), 27.4%; t(6;11), 21.5%. The incidence of patients with t(11;19) was higher than those in the US and Europe, and the incidence of t(4;11) was lower than that in childhood. The results indicated the poor prognosis of AML with 11q23 abnormalities regardless of the fusion partners. AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo-HSCT, although the differences were not statistically significant (P = 0.322 for DFS, P = 0.138 for OS). This result suggests that treatment strategies including allo-HSCT may be considered in the first CR in cases of AML with 11q23 abnormalities. However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities.
Authors:
Hayato Tamai; Hiroki Yamaguchi; Hiroyuki Hamaguchi; Fumiharu Yagasaki; Masami Bessho; Takeshi Kobayashi; Hideki Akiyama; Hisashi Sakamaki; Satoshi Takahashi; Arinobu Tojo; Ken Ohmine; Keiya Ozawa; Hirokazu Okumura; Shinji Nakao; Ayako Arai; Osamu Miura; Shigeo Toyota; Seiji Gomi; Yoshiro Murai; Noriko Usui; Keisuke Miyazawa; Kazuma Ohyashiki; Naoto Takahashi; Kenichi Sawada; Atsushi Kato; Kazuo Oshimi; Koiti Inokuchi; Kazuo Dan
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-02-06
Journal Detail:
Title:  International journal of hematology     Volume:  87     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
Affiliation:
Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, Japan. s6056@nms.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromosomes, Human, Pair 11 / genetics*
Cohort Studies
Disease-Free Survival
Female
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute / genetics*,  therapy
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*,  therapy
Retrospective Studies
Translocation, Genetic / genetics*
Transplantation, Homologous

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