Document Detail

Clinical features of Sjogren's syndrome in patients with multiple sclerosis.
MedLine Citation:
PMID:  20809902     Owner:  NLM     Status:  In-Data-Review    
Annunziata P, De Santi L, Di Rezze S, Millefiorini E, Capello E, Mancardi G, De Riz M, Scarpini E, Vecchio R, Patti F. Clinical features of Sjogren's syndrome in patients with multiple sclerosis. Acta Neurol Scand: 2011: 124: 109-114. © 2010 John Wiley & Sons A/S. Objectives -  To assess the frequency of clinical features of Sjogren's syndrome (SS) in patients with multiple sclerosis (MS) receiving treatment with disease-modifying drugs (DMDs) or naïve to treatment and the possible association with clinical, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) parameters. Methods -  A multicentre cross-sectional observational study was designed, based on a structured neurologist-administered questionnaire to 440 patients. Results -  Twenty-eight of 230 (12%) patients receiving treatment with DMDs (DMDs(+) ) and 14 of 210 (6.6%) treatment-naïve patients (DMDs(-) ) showed clinical features of SS. Four primary SS were diagnosed, two of which were DMDs(+) and two were DMDs(-) . Sicca symptoms were significantly associated with higher EDSS scores (P = 0.018), a low frequency of gadolinium-enhanced MRI-positive lesions (P = 0.018) and cerebral disturbances (P = 0.001). Conclusions -  Screening for the clinical features of SS should be performed in patients with MS both receiving treatment with immunomodulatory drugs and without therapy.
P Annunziata; L De Santi; S Di Rezze; E Millefiorini; E Capello; G Mancardi; M De Riz; E Scarpini; R Vecchio; F Patti
Publication Detail:
Type:  Journal Article     Date:  2010-08-31
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  124     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Siena Department of Neurological Sciences, University of Rome, Roma Department of Neurological Sciences, Ophthalmology and Genetics, University of Genova, Genova Department of Neurological Sciences, University of Milan, Milan Department of Neurosciences, University of Catania, Catania, Italy.
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