Document Detail


Clinical features of HIV-seropositive and HIV-seronegative patients with tuberculous pleural effusion in Dar es Salaam, Tanzania.
MedLine Citation:
PMID:  7956405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a prospective study, we investigated whether human immunodeficiency virus (HIV) infection alters the clinical presentation in patients with tuberculous pleuritis. One hundred twelve of 118 patients who presented with pleural effusion suffered from tuberculosis (TB); 65 patients (58%) were HIV seropositive. Evidence of disseminated TB was found more often in HIV-positive than in HIV-negative patients (30.8% vs 10.6%, p < 0.02). Dyspnea, fever, night sweat, fatigue, and diarrhea, severe tachypnea, hepatomegaly, splenomegaly, and lymphadenopathy were significantly more common in HIV-infected than in HIV-negative patients with TB. The same applied to a negative Mantoux reaction, lower hemoglobin, higher beta 2-microglobulin values, and in pleural fluid, lower albumin and higher gamma-globulin levels. Among HIV-infected patients, PPD skin test anergy was significantly associated with relative low albumin and gamma-globulin levels of pleural fluid. However, the radiographic features did not differ with respect to HIV status; they were predominantly those of primary pleuritis (78% in each group). We conclude that coexisting HIV infection affects clinical and laboratory features, but not the radiographic presentation of patients with TB pleuritis in Tanzania.
Authors:
C Richter; R Perenboom; I Mtoni; J Kitinya; H Chande; A B Swai; R R Kazema; L M Chuwa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  106     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-09     Completed Date:  1994-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1471-5     Citation Subset:  AIM; IM; X    
Affiliation:
Department of Medicine, Muhimbili Medical Centre, Dar es Salaam, Tanzania.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / diagnosis*
Adult
Chi-Square Distribution
Female
HIV Seronegativity*
HIV Seropositivity / diagnosis*
HIV-1 / immunology*
Humans
Lung / radiography
Male
Pleural Effusion / diagnosis*
Prospective Studies
Tanzania
Tuberculin Test
Tuberculosis, Pleural / diagnosis*
Urban Population*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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