| Clinical features of Black African neonates with Down's syndrome. | |
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MedLine Citation:
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PMID: 7555887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early reports indicated a low prevalence of Down's syndrome (DS) in black African children. More recent research demonstrates an incidence similar to, or higher than that reported to occur in First World populations. One of the possible reasons for underreporting of DS in Africa, appears to be the lack of recognition of the problem at birth. In this study, the musculoskeletal, central nervous system and craniofacial features are documented in 40 black DS neonates and 50 black control neonates without DS, and the findings are compared with those from a reported series of 37 caucasian DS and 40 healthy newborns. Musculoskeletal and central nervous system features were markedly similar in black and caucasian infants. However, the craniofacial features of the African DS newborns approximated more closely those of the normal African neonates, than was the case in the caucasian DS and normal neonates. This finding may partially explain the underreporting of DS in this population, and it emphasizes the need for a clinical awareness of DS and for complete clinical examination to identify affected infants. |
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Authors:
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A L Christianson; J G Kromberg; E Viljoen |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: East African medical journal Volume: 72 ISSN: 0012-835X ISO Abbreviation: East Afr Med J Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-10-24 Completed Date: 1995-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372766 Medline TA: East Afr Med J Country: KENYA |
Other Details:
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Languages: eng Pagination: 306-10 Citation Subset: IM |
Affiliation:
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Department of Human Genetics and Developmental Biology, Faculty of Medicine, University of Pretoria, Republic of South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Africa / epidemiology African Continental Ancestry Group* Case-Control Studies Down Syndrome / epidemiology, genetics*, pathology*, prevention & control European Continental Ancestry Group Female Humans Incidence Infant, Newborn Male Prevalence Sweden |
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