| Clinical factors associated with cancer-related fatigue in patients being treated for leukemia and non-Hodgkin's lymphoma. | |
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MedLine Citation:
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PMID: 11870175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe fatigue severity, fatigue interference, and associated factors in hematologic malignancies. PATIENTS AND METHODS: Patients being treated for leukemia and non-Hodgkin's lymphoma (n = 228) completed the Brief Fatigue Inventory to rate fatigue severity and functional interference caused by fatigue. Data on patient demographics, Eastern Cooperative Oncology Group performance status, other physical symptoms, current treatments, and laboratory values were also collected. Descriptive statistics, bivariate correlation, and logistic regression were used for data analysis. RESULTS: Fifty percent of the sample reported severe fatigue, which was defined as a "fatigue worst" rating of 7 or greater. More patients with acute leukemia (61%) reported severe fatigue compared with those with chronic leukemia (47%) and non-Hodgkin's lymphoma (46%). Increased fatigue severity significantly compromised patients' general activity, work, enjoyment of life, mood, walking, and relationships with others. Fatigue severity was strongly associated with performance status, use of opioids, blood transfusions, gastrointestinal symptoms, and sleep disturbance items, as well as with low serum hemoglobin and albumin levels. Regression analysis indicated that nausea was the significant clinical predictor of severe fatigue (odds ratio, 13), and low serum albumin was the significant laboratory value predictor (odds ratio, 3.8). CONCLUSION: Disabling fatigue occurs with high frequency in hematologic malignancy, supporting a need to develop better methods of fatigue management. Better control of gastrointestinal and other symptoms may be of benefit. The mechanism and relationship between low albumin and severe fatigue needs to be investigated further, and longitudinal studies of the effects of treatment, host factors, and other symptoms are needed. |
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Authors:
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Xin Shelley Wang; Sergio A Giralt; Tito R Mendoza; Martha C Engstrom; Beth A Johnson; Neomi Peterson; Lyle D Broemeling; Charles S Cleeland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: 20 ISSN: 0732-183X ISO Abbreviation: J. Clin. Oncol. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-28 Completed Date: 2002-04-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1319-28 Citation Subset: IM |
Affiliation:
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Department of Symptom Research, Division of Anesthesiology and Critical Care, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. swong@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Acute Disease Adolescent Adult Aged Aged, 80 and over Fatigue / epidemiology, etiology*, physiopathology Female Humans Leukemia / complications*, therapy* Lymphoma, Non-Hodgkin / complications*, therapy* Male Middle Aged Prevalence Serum Albumin / analysis Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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CA 26582/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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