| Clinical and experimental studies on electromechanical dissociation. | |
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MedLine Citation:
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PMID: 7237718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electromechanical dissociation (EMD) is the most frequent cause of unsuccessful cardiac resuscitation in critically ill patients. In a clinical study of cardiac arrest, including 54 episodes in 50 fully monitored patients, 14 episodes of ventricular fibrillation were observed and seven were reversed. In the remaining 40 instances, 36 cases of EMD were initially observed. Four patients had asystole. None of the patients with EMD or asystole were successfully resuscitated. For objective study of EMD and its treatment, we developed an experimental model in which ventricular fibrillation was induced in mechanically ventilated dogs. EMD was predictably observed when, after an interval of 120 seconds, ventricular fibrillation was reversed with an external countershock. Neither metabolic acidosis nor metabolic alkalosis modified the incidence of EMD. A few dogs were pretreated with glucose-insulin-potassium or pharmacologic doses of methylprednisolone, but this did not clearly reduce the incidence of EMD. However, the onset of EMD was delayed when the body temperature of the animal was spontaneously reduced. |
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Authors:
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J L Vincent; L Thijs; M H Weil; S Michaels; R A Silverberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 64 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 18-27 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Blood Pressure* / drug effects Cardiac Output* Dogs Electric Stimulation Electrocardiography* Female Heart Arrest / complications, etiology* Heart Rate Hemodynamics Humans Male Methylprednisolone / pharmacology Middle Aged Resuscitation Time Factors Vascular Resistance / drug effects Ventricular Fibrillation / complications |
| Grant Support | |
ID/Acronym/Agency:
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GM 16462/GM/NIGMS NIH HHS; R01 HL 23015/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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