Document Detail

Clinical experiences with pipecuronium bromide.
MedLine Citation:
PMID:  6322488     Owner:  NLM     Status:  MEDLINE    
In two groups of patients the neuromuscular and circulatory effects of pipecuronium bromide (Arduan R), a new steroid type muscle relaxant were compared with those of pancuronium during balanced anaesthesia. Pipecuronium (n = 18) was found to be about 20% more potent than pancuronium (n = 20). The 95% blocking doses were: 0.059 mg kg-1 for pipecuronium and 0.075 mg kg-1 for pancuronium; these doses provided equal intubating conditions and relaxation. The onset, clinical relaxation time (clinical duration), recovery and the reversibility of the neuromuscular effects of the two agents in equipotent doses were similar. No cardiovascular or other side effects were observed with the use of pipecuronium.
M Boros; J Szenohradszky; A Kertész; G Marosi; L Tutsek
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta chirurgica Hungarica     Volume:  24     ISSN:  0231-4614     ISO Abbreviation:  Acta Chir Hung     Publication Date:  1983  
Date Detail:
Created Date:  1984-04-25     Completed Date:  1984-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309977     Medline TA:  Acta Chir Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  207-14     Citation Subset:  IM    
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MeSH Terms
Androstane-3,17-diol / administration & dosage,  analogs & derivatives,  pharmacology*
Androstanols / pharmacology*
Anesthesia, General
Blood Pressure / drug effects
Heart Rate / drug effects
Neuromuscular Blocking Agents / administration & dosage,  pharmacology*
Neuromuscular Nondepolarizing Agents / administration & dosage,  pharmacology*
Pancuronium / pharmacology*
Piperazines / administration & dosage,  pharmacology*
Surgical Procedures, Operative
Time Factors
Reg. No./Substance:
0/Androstanols; 0/Neuromuscular Blocking Agents; 0/Neuromuscular Nondepolarizing Agents; 0/Pancuronium; 0/Piperazines; 25126-76-5/Androstane-3,17-diol; 68399-58-6/Pipecuronium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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