Document Detail

Clinical experience with alfentanil for induction of anaesthesia; a comparison with thiopentone.
MedLine Citation:
PMID:  6437644     Owner:  NLM     Status:  MEDLINE    
Alfentanil, a new short-acting narcotic was clinically evaluated as an intravenous anaesthetic induction agent in 19 patients and compared to 20 patients receiving thiopentone. Alfentanil was superior to thiopentone in cardiovascular stability, both during induction of anaesthesia and tracheal intubation. However, alfentanil does not behave like a typical induction agent, time to unconsciousness is longer and more variable and is often accompanied by muscle rigidity. The results of this study suggest that alfentanil is more difficult to use as an induction agent than thiopentone, but alfentanil is recommended for short procedures when haemodynamic stability is important.
M G Palazzo; S Taylor; L Strunin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  31     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous*
Arousal / drug effects
Fentanyl / analogs & derivatives*
Hemodynamics / drug effects
Surgery, Plastic*
Reg. No./Substance:
437-38-7/Fentanyl; 71195-58-9/Alfentanil; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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