Document Detail


Clinical experience with Andriol Testocaps--the first Austrian surveillance study on the treatment of late-onset hypogonadism.
MedLine Citation:
PMID:  18033627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to document the efficacy and tolerability of the new formulation of Andriol Testocaps in the treatment of late-onset hypogonadism in a clinical practice setting. METHODS: The primary inclusion criterion was symptomatic testosterone deficiency, as confirmed by laboratory testing (morning total testosterone <12 nmol/L) on two separate occasions. The study was performed in 43 centres in Austria and a dosage of oral testosterone undecanoate of 2 x 80 mg/day was used for three months. The ADAM questionnaire, the AMS scale and the SF-36 questionnaire were administered by the patients and specific questions were asked to the prescribers. RESULTS: A total of 189 patient report forms and 185 doctor report forms were completed. The average age of the participants was 54.7 +/- 12.3 years and average treatment duration was 13.9 +/- 2.2 weeks. Serum testosterone level increased by more than 50% from 8.7 +/- 4.3 nmol/L to 13.2 +/- 6.7 nmol/L (p < 0.001). Treatment improved symptoms on the ADAM and AMS scales, whereas no changes were observed on the SF-36. There were no significant effects on serum PSA levels. CONCLUSION: Short-term treatment with oral testosterone undecanoate in a clinical practice setting improved late-onset hypogonadism symptoms in aging men with low testosterone levels.
Authors:
Andreas Jungwirth; Eugen Plas; Paul Geurts
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The aging male : the official journal of the International Society for the Study of the Aging Male     Volume:  10     ISSN:  1368-5538     ISO Abbreviation:  Aging Male     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-22     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808210     Medline TA:  Aging Male     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Affiliation:
Department of Urology and Andrology, EMCO Private Clinic, Martin Hell Strasse 7-9, Bad Dürrnberg, Austria. urologie@emco-klinik.at
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Austria
Humans
Hypogonadism / blood,  drug therapy*,  epidemiology
Male
Middle Aged
Prostate-Specific Antigen / blood
Testosterone / administration & dosage,  analogs & derivatives*,  blood
Testosterone Congeners / administration & dosage*
Chemical
Reg. No./Substance:
0/Testosterone Congeners; 58-22-0/Testosterone; 5949-44-0/testosterone undecanoate; EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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