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Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure.
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MedLine Citation:
PMID:  10346997     Owner:  NLM     Status:  MEDLINE    
This is a review of exposure conditions, clinical presentation, and morbidity of children and adults with indoor fungal exposure such as toxic Stachybotrys chartarum. Indoor exposure was characterized using different methods including microscopic, culture, cytotoxicity screening tests, and chemical analyses. Clinical case histories and physical and laboratory findings are presented of children (age < 18 years, n = 22; mean age 9 years; 60% females) and adults (age >18 years, n = 125; mean age 39 years, 67% females) who consulted an environmental health specialty clinic. In the pediatric patients' exposure history, widespread fungal contamination of water-damaged building materials with known toxic or allergic fungi was identified. Primarily disorders of the respiratory system, skin, mucous membranes, and central nervous system were reported. Some enumeration and functional laboratory abnormalities, mainly of the lymphatic blood cells, were observed, although no statistically significant differences were found. IgE or IgG fungi-specific antibodies, used as exposure markers, were positive in less than 25% of all tested cases. In an evaluation of a symptomatic girl 11 years of age (sentinel case investigation) living in an apartment with verified toxigenic fungi (i.e., S. chartarum), several health indicators showed improvement after exposure cessation.
E Johanning; P Landsbergis; M Gareis; C S Yang; E Olmsted
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  107 Suppl 3     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  489-94     Citation Subset:  IM    
Mount Sinai School of Medicine, New York, NY, USA.
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MeSH Terms
Air Pollution, Indoor / adverse effects*
Allergens / analysis
Cockroaches / immunology
Environmental Exposure
Environmental Health
Environmental Microbiology*
Fungi / isolation & purification,  pathogenicity*
Pesticides / adverse effects,  analysis
Respiratory Tract Diseases / etiology,  immunology
Sentinel Surveillance
Skin Diseases / etiology,  immunology
Reg. No./Substance:
0/Allergens; 0/Pesticides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 1999
Volume: 107 Issue: Suppl 3
First Page: 489 Last Page: 494
ID: 1566219
PubMed Id: 10346997
Publisher Item Identifier: sc271_5_1835

Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure.
E Johanning
P Landsbergis
M Gareis
C S Yang
E Olmsted
Mount Sinai School of Medicine, New York, NY, USA.

Article Categories:
  • Research Article

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