Document Detail


Clinical experience of recombinant human erythropoietin in uremic children: report of three cases.
MedLine Citation:
PMID:  8935379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anemia due to decreased erythropoietin production is one of the major complications in uremic patients. The aim of the study is to evaluate the clinical efficiency and safety of rHuEPO in the treatment of anemia in uremic children receiving regular hemodialysis. Three uremic children, age 8, 12, and 14 year-old, under maintenance hemodialysis with hematocrit (Hct) value lower than 20% were observed for 6 months. rHuEPO 50 u/kg were given intravenously three times a week initially. Hct value of 30% was the target of therapy. All 3 children responded to the therapy and reached the target Hct value within 11 to 18 weeks. They received no further transfusion after the therapy. The maintenance dose to keep Hct value around 30% is 75 to 120 u/kg/wk. The serum biochemistry examination showed no difference before and after the therapy. The physical endurance, body weight and height increased in all children. The left ventricular end-diastolic dimension in echocardiography decreased and the ejection fraction increased after 6 months of the treatment. Serum ferritin concentrations decreased in all children. Mild hypertension developed in one child. Heparin dose was increased when the target Hct value was around 30% in 2 children. We suggested that low dose rHuEPO therapy was safe and effective in uremic children, but close monitoring for the development of hypertension and iron deficiency was mandatory.
Authors:
F R Chuang; M S Wu; M L Leu; C C Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital     Volume:  19     ISSN:  -     ISO Abbreviation:  Changgeng Yi Xue Za Zhi     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-01-06     Completed Date:  1997-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9809559     Medline TA:  Changgeng Yi Xue Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anemia / therapy*
Child
Erythropoietin / therapeutic use*
Humans
Recombinant Proteins / therapeutic use
Uremia / complications*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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