Document Detail


Clinical evidence for heterogeneity in myotonic dystrophy.
MedLine Citation:
PMID:  7143387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a study of 35 index patients who developed myotonic dystrophy between birth and 30 years (neonatal cases aware excluded), 30 could be categorised into two clinical types. The 13 type 1 patients had a more severe limb weakness, of patchy distribution, associated with proportional facial weakness. The 17 type 2 patients had a milder and more diffuse limb weakness; their facial weakness, however, was very pronounced and preceded the limb weakness by several years. All but one of the 25 affected relatives who were examined belonged to the same category as their index relative, providing evidence that the cause of the clinical heterogeneity was genetic. Subsequent observations showed that mental retardation, male infertility, and neonatally affected offspring were commoner in type 2 patients. Congenital myotonic dystrophy could occur among the offspring of either affected males or affected females, but neonatal symptoms were confined to the offspring of affected women. The overall risk for having neonatally affected offspring for this prospective study of young adult patients was 7 in 38, and for the offspring of affected females 7 in 27. The risk for having a surviving child whose mental or physical handicap or both required special schooling was 1 in 12 for males and 4 in 27 for females.
Authors:
S Bundey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical genetics     Volume:  19     ISSN:  0022-2593     ISO Abbreviation:  J. Med. Genet.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985087R     Medline TA:  J Med Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Clubfoot / genetics
Facial Muscles / physiopathology
Female
Genes, Dominant
Humans
Infertility, Male / genetics
Male
Mental Retardation / genetics
Middle Aged
Myotonic Dystrophy / genetics*
Prospective Studies
Risk
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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