| Clinical events following excimer laser angioplasty or balloon angioplasty for complex coronary lesions: subanalysis of a randomised trial. | |
| | |
MedLine Citation:
|
PMID: 9505916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To compare clinical outcome in patients with complex coronary lesions treated with either excimer laser coronary angioplasty (ELCA) or balloon angioplasty. PATIENTS AND DESIGN: 308 patients with stable angina and a coronary lesion of more than 10 mm in length were randomised to ELCA (151 patients, 158 lesions) or balloon angioplasty (157 patients, 167 lesions). The primary clinical end points were death, myocardial infarction, coronary bypass surgery, or repeated coronary angioplasty of the randomised segment during six months of follow up. Subanalysis was performed to identify a subgroup of patients with a beneficial clinical outcome following ELCA or balloon angioplasty. SETTING: Two university hospitals and one general hospital. RESULTS: There were no deaths. Myocardial infarction, coronary bypass surgery, and repeated angioplasty occurred in 4.6, 10.6, and 21.2%, respectively, of patients treated with ELCA compared with 5.7, 10.8, and 18.5%, respectively, of those treated with balloon angioplasty. ELCA did not yield a favourable clinical outcome in subgroups of patients with long (more than 20 mm) coronary lesions, calcified lesions, small diseased vessels (< or = 2.5 mm reference diameter), or total coronary occlusions. There was a worse clinical outcome in patients with tandem lesions treated with ELCA compared with balloon angioplasty (9/18 v 3/26 lesions; p = 0.01); while a trend towards an unfavourable clinical outcome was found in patients with vessels with a reference diameter of more than 2.5 mm (23/66 v 13/63 lesions, p = 0.07) and left circumflex coronary lesions (12/41 v 6/42 lesions, p = 0.08). CONCLUSIONS: The findings indicate a worse clinical outcome in patients with lesions of more than 10 mm treated with ELCA compared with balloon angioplasty who have tandem coronary lesions and in those with vessels with a reference diameter of more than 2.5 mm and left circumflex coronary lesions. |
| | |
Authors:
|
Y E Appelman; J J Piek; W K Redekop; P J de Feyter; J J Koolen; G K David; S Strikwerda; J G Tijssen; P W Serruys; E van Swijndregt; M J van Gemert; K I Lie |
Related Documents
:
|
10785716 - Primary ptca in a rural hospital. 9283726 - Anatomic variant of the posterior interventricular coronary artery: implications for co... 11113406 - Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-co... 2521226 - Thrombolysis and angioplasty in myocardial infarction (tami-1) trial: influence of infa... 3598736 - Cardiac morbidity and mortality associated with occupational exposure to 1,2 propylene ... 18162196 - Up-regulation of ppargamma in myocardial infarction. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 79 ISSN: 1355-6037 ISO Abbreviation: Heart Publication Date: 1998 Jan |
Date Detail:
|
Created Date: 1998-03-23 Completed Date: 1998-03-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 34-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiology, University of Amsterdam, Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Balloon* Angioplasty, Balloon, Laser-Assisted* Chi-Square Distribution Coronary Angiography Coronary Artery Bypass Coronary Disease / mortality, surgery, therapy* Coronary Vessels / pathology Evaluation Studies as Topic Female Follow-Up Studies Humans Male Reoperation Treatment Outcome |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early and intermediate term clinical outcome after multiple coronary stenting.
Next Document: Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to...