| Clinical evaluation of three different gonadotrophin-releasing hormone analogues in an IVF programme: a prospective study. | |
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MedLine Citation:
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PMID: 12069736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of short acting buserelin and nafarelin intranasal spray were compared to long acting leuprorelin depot intramuscular or subcutaneous injection in this prospective study of 157 women undergoing controlled ovarian hyperstimulation (COH) for in-vitro fertilisation (IVF). Patients were allocated to three groups to receive buserelin 150 microg nasal spray three times daily (Group B), nafarelin nasal spray 400 microg twice daily (Group N), or leuprorelin depot 3.75 mg once by intramuscular or subcutaneous injection (Group L) for pituitary desensitisation prior to commencing COH with human menopausal gonadotrophins (hMG) according to the Centre's protocol. The mean (+/-S.D.) age (years) (32.6+/-3.8: Group B, 32.1+/-3.3: Group N versus 32.1+/-3.3: Group L); mean (+/-S.D.) total dosage of hMG (ampoules) (37.5+/-16.1: Group B, 39.8+/-14.2: Group N versus 41.9+/-12.6: Group L) and mean daily dosage of hMG (ampoules) (3.1: Group B, 2.8: Group N versus 3.0: Group L) seen were not statistically significantly different. The duration between starting the different gonadotrophin-releasing hormone (GnRHa) and the beginning of the next menstrual period was also not seen to be statistically significantly different between the three groups (Group B: 10+/-5.5, Group N: 9.1+/-4.1 versus Group L: 8.2+/-3, days). The number of abandoned cycles was higher in Group L (17% versus 11.8%: Group B and 11.3%: Group N) but this difference did not reach statistical significance. The clinical pregnancy rates per oocyte retrieval and per embryo transfer procedure were respectively, 31.1, 35% in Group B, 12.8, 14% in Group N versus 20.5, 23.7 in Group L and were not seen to be statistically significantly different even when ongoing pregnancy rates were compared. Apart from a statistically significantly greater incidence of allergic nasal reactions in the nafarelin group (P=0.001), all other side-effects were not shown to be statistically significantly different between the three groups. We conclude that a single dose of leuprorelin depot can be considered to be as an equally effective alternative to multiple doses of buserelin or nafarelin for pituitary desensitisation in women undergoing COH for IVF. |
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Authors:
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A El-Nemr; M Bhide; Y Khalifa; E Al-Mizyen; C Gillott; A M Lower; T Al-Shawaf; J G Grudzinskas |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 103 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-18 Completed Date: 2003-01-22 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM |
Affiliation:
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Fertility Centre, Royal Hospitals NHS Trust, St Bartholomew's Hospital, West Smithfield, EC1A, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Adult Buserelin / administration & dosage, adverse effects Embryo Transfer Female Fertility Agents, Female / administration & dosage*, adverse effects Fertilization in Vitro Gonadotropin-Releasing Hormone / analogs & derivatives Humans Leuprolide / administration & dosage, adverse effects Menotropins / therapeutic use Nafarelin / administration & dosage, adverse effects Oocytes / physiology Ovulation Induction / methods* Pregnancy Pregnancy Rate Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide; 57982-77-1/Buserelin; 61489-71-2/Menotropins; 76932-56-4/Nafarelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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