Document Detail

Clinical evaluation of a solid-phase test for red cell antibody screening of pregnant women.
MedLine Citation:
PMID:  9920163     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aims of this study were to evaluate the results of a new solid-phase screening test for detecting atypical red cell (RBC) antibodies in a large number of pregnant women and to compare these results to the clinical outcome of the newborn. STUDY DESIGN AND METHODS: A total of 38,700 infants born in Stockholm were studied retrospectively. Of these infants, 18,500 were born to pregnant women screened with the solid-phase test. Data were collected on all newborns with a positive direct antiglobulin test (DAT) and on infants requiring an exchange transfusion or a blood transfusion. These data were correlated to the screening results for the mothers. RESULTS: Of 409 DAT-positive newborns, a serologic explanation for the positive DAT was found in 349. Three hundred four cases were due to ABO incompatibility between mother and child; 19 of these infants needed an exchange transfusion. Forty-two cases were due to unexpected maternal RBC antibodies; 11 of these infants were given an exchange transfusion. All 11 were identified before birth. Three other infants had DAT-positive tests due to ABO incompatibility and to unexpected maternal RBC antibodies. CONCLUSION: ABO incompatibility is a major indication for exchange transfusion in DAT-positive newborns. There was no evidence that the solid-phase screening test had failed to detect any clinically significant RBC antibodies. Finally, the results of this study do not indicate a need for routine screening of D+ women more than once during each pregnancy.
A Shanwell; S Sallander; K Bremme; M Westgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  39     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-03     Completed Date:  1999-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  IM    
Stockholm Blood Transfusion Center, South Hospital, Sweden.
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MeSH Terms
ABO Blood-Group System
Blood Group Incompatibility
Coombs' Test / methods
Evaluation Studies as Topic
Infant, Newborn
Isoantibodies / blood*
Mass Screening
Pregnancy / blood*
Rh Isoimmunization / diagnosis*
Reg. No./Substance:
0/ABO Blood-Group System; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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