| Clinical evaluation of a solid-phase test for red cell antibody screening of pregnant women. | |
| | |
MedLine Citation:
|
PMID: 9920163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The aims of this study were to evaluate the results of a new solid-phase screening test for detecting atypical red cell (RBC) antibodies in a large number of pregnant women and to compare these results to the clinical outcome of the newborn. STUDY DESIGN AND METHODS: A total of 38,700 infants born in Stockholm were studied retrospectively. Of these infants, 18,500 were born to pregnant women screened with the solid-phase test. Data were collected on all newborns with a positive direct antiglobulin test (DAT) and on infants requiring an exchange transfusion or a blood transfusion. These data were correlated to the screening results for the mothers. RESULTS: Of 409 DAT-positive newborns, a serologic explanation for the positive DAT was found in 349. Three hundred four cases were due to ABO incompatibility between mother and child; 19 of these infants needed an exchange transfusion. Forty-two cases were due to unexpected maternal RBC antibodies; 11 of these infants were given an exchange transfusion. All 11 were identified before birth. Three other infants had DAT-positive tests due to ABO incompatibility and to unexpected maternal RBC antibodies. CONCLUSION: ABO incompatibility is a major indication for exchange transfusion in DAT-positive newborns. There was no evidence that the solid-phase screening test had failed to detect any clinically significant RBC antibodies. Finally, the results of this study do not indicate a need for routine screening of D+ women more than once during each pregnancy. |
| | |
Authors:
|
A Shanwell; S Sallander; K Bremme; M Westgren |
Related Documents
:
|
1541133 - Pleural determinants of restrictive lung function and respiratory symptoms in an asbest... 11113683 - Correction of cor triatriatum sinistrum in a jehovah's witness infant. 19336373 - Endostatin concentration in cord plasma predicts the development of bronchopulmonary dy... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transfusion Volume: 39 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 1999 Jan |
Date Detail:
|
Created Date: 1999-02-03 Completed Date: 1999-02-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0417360 Medline TA: Transfusion Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 26-31 Citation Subset: IM |
Affiliation:
|
Stockholm Blood Transfusion Center, South Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ABO Blood-Group System Blood Group Incompatibility Coombs' Test / methods Evaluation Studies as Topic Female Humans Infant, Newborn Isoantibodies / blood* Mass Screening Pregnancy / blood* Rh Isoimmunization / diagnosis* Sweden |
| Chemical | |
Reg. No./Substance:
|
0/ABO Blood-Group System; 0/Isoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Site-directed mutagenesis of the human D antigen: definition of D epitopes on the sixth external dom...
Next Document: NOR polyagglutination and Sta glycophorin in one family: relation of NOR polyagglutination to termin...