| Clinical evaluation of a single-wavelength fractional laser and a novel multi-wavelength fractional laser in the treatment of photodamaged skin. | |
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MedLine Citation:
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PMID: 19588529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Nonablative fractional lasers are well recognized for rejuvenating photoaged skin. We previously reported favorable outcomes with short follow-up after the use of 1,440-nm Nd:YAG laser energy used alone or in combination with a 1,320-nm laser to effect rejuvenation and wrinkle reduction. We now report longer follow-up data. STUDY DESIGN/MATERIALS AND METHODS: Nineteen Caucasian subjects (average age 47+/-8.4; range 33-62) exhibiting mild-to-moderate photoaging of the face and neck were treated four times (average interval 18.1+/- 4.1 days; range 11-37 days) with the 1,440-nm Nd:YAG fractional laser (average fluence 3.7+/-0.3 J/cm(2)) or the 1,320/1,440-nm multiplex Nd:YAG fractional laser (1,320-nm average fluence 8.4+/-0.4 J/cm(2); 1,440-nm average fluence 2.3+/-0.2 J/cm(2)). Outcomes were assessed by subjects and the treating physician using a quartile scale to evaluate skin tightening, surface texture, rhytids, dyschromia, erythema, and global appearance after 1, 3, and 6 months. Retroauricular punch biopsies from three patients were used to evaluate wound healing. Three patients withdrew from the study prior to evaluation, one missed the 1-month evaluation, and one missed the 6-month evaluation. RESULTS: Assessment by subjects and the treating physician revealed clinical improvement for all outcomes after 1, 3, and 6 months. The differences between the treatment groups were not statistically significant. Subjects demonstrated the greatest average 6-month improvements in surface texture and global skin appearance. Subjects treated with the multiplex laser reported more skin tightening than the group treated only with the 1,440-nm laser. Histological evaluation revealed wound healing within 10 days and significant neocollagenesis at 3 months. No adverse events were reported in any subject. CONCLUSION: The 1,440-nm Nd:YAG and 1,320/1,440-nm multiplex Nd:YAG lasers safely and effectively produced improved surface texture, rhytids, dyschromia, erythema, global skin appearance, and skin tightening. Histopathologic findings correlated with clinical observations. |
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Authors:
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Laurel Naversen Geraghty; Brian Biesman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 41 ISSN: 1096-9101 ISO Abbreviation: Lasers Surg Med Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-15 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 408-16 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Ophthalmology, Otolaryngology, Dermatology, Vanderbilt University Medical Center Laser and Facial Surgery, 345 23rd Ave., N. Suite 416, Nashville, Tennessee 37203, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dose Fractionation Face Female Follow-Up Studies Humans Laser Therapy / instrumentation*, methods Lasers, Solid-State / therapeutic use* Male Middle Aged Patient Satisfaction Skin Aging / pathology, radiation effects* Skin Pigmentation / radiation effects Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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