| Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. | |
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MedLine Citation:
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PMID: 22043069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW). |
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Authors:
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Stéphanie Claeys; Frederico Rustichelli; Stéphanie Noël; Annick Hamaide |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian veterinary journal. La revue vétérinaire canadienne Volume: 52 ISSN: 0008-5286 ISO Abbreviation: Can. Vet. J. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-11-01 Completed Date: 2012-01-09 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0004653 Medline TA: Can Vet J Country: Canada |
Other Details:
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Languages: eng Pagination: 501-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences (Companion Animals), Faculty of Veterinary Medicine, University of Liège, boulevard de Colonster, 20, B44, 4000 Liège, Belgium. Stephanie.Claeys@ulg.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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administration & dosage,
therapeutic use* Animals Dog Diseases / drug therapy* Dogs Drug Administration Schedule / veterinary Female Phenylpropanolamine / administration & dosage, therapeutic use* Retrospective Studies Treatment Outcome Urinary Incontinence / drug therapy, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 14838-15-4/Phenylpropanolamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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