Document Detail


Clinical evaluation of roxithromycin: a double-blind, placebo-controlled and crossover trial in patients with acne vulgaris.
MedLine Citation:
PMID:  14739496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We clinically evaluated roxithromycin (ROM) in a double blind, placebo-controlled, and crossover trial in patients with inflammatory acne. Patients with inflammatory acne who were attending our outpatient clinic for treatment and who had not received topical or systemic treatment for the previous month were enrolled in this study. Patients were randomly separated into two groups. Group I consisted of 26 patients. The patients received 2x150 mg/day ROM orally in the first period and 2x1 placebo tablets/day in the second period. Group II consisted of 20 patients. These patients received 2x1 placebo tablets/day in the first period and 2x150 mg/day ROM orally in the second period. The first period was the first four weeks, and then there was a washout period of two weeks (5th and 6th). The second period was the next four weeks (7th to 10th weeks) after the washout period. Median acne scores had clearly decreased in both groups at the end of the study. Differences of median acne scores were statistically significant in both groups between at baseline and at the end of the study (p<0.001). The results showed that ROM is a safe and effective alternative in the treatment of inflammatory acne with few side effects and good compliance.
Authors:
Ayten Ferahbas; Serap Utas; Deniz Aykol; Murat Borlu; Umit Uksal
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of dermatology     Volume:  31     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  6-9     Citation Subset:  IM    
Affiliation:
Erciyes University, School of Medicine, Department of Dermatology, Kayseri, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / diagnosis,  drug therapy*
Administration, Oral
Adolescent
Adult
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Probability
Reference Values
Risk Assessment
Roxithromycin / administration & dosage*
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
80214-83-1/Roxithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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