Document Detail

Clinical evaluation of oxidative stress and myocardial reperfusion injury in pediatric cardiac surgery.
MedLine Citation:
PMID:  12124549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To evaluate oxidative stress and myocardial damage after aortic crossclamping release (ACCR) during cardio pulmonary bypass (CPB) in children two parameters were investigated: total glutathione (GSH) and its oxidoreductive reactions (GSH/GSSG) as expression of oxidative stress, and plasmatic turnover of myocardial taurine (TAU) as expression of cell damage. METHODS: The study was divided in two periods: 1) first period: analysis of oxidative stress and myocardial damage in 18 children. 2) Second period: evaluation of myocardial cell protection by controlled anterograde low oxygen warm reperfusion (ALOWR) before declamping. Twenty-one children were divided in two groups: not receiving (Group 1, 9 patients) and receiving (Group 2, 12 patients) ALOWR. RESULTS: In the first period GSH values increased significantly after onset of mechanical ventilation (MV) in vein, after CPB start in artery and after ACCR in coronary sinus. Moreover TAU turnover in aortic and coronary sinus blood increased significantly after ACCR. In the second period, Group 2 showed a lower oxidative stress after ACCR, while no differences were observed in TAU turnover. CONCLUSIONS: 1) Assessment of TAU and GSH levels can be considered a good method to clinically evaluate myocardial injury during cardiac surgery. 2) MV and CPB can induce oxidative stress before aortic clamping and can decrease the physiologic scavengers. Therefore, to prevent that depletion, the strategy of these techniques must be adapted to the patient and to his cardiac disease. 3) Intramyocardial TAU turnover is not significantly modified by the reperfusion technique. 4) ALOWR can reduce myocardial oxidative stress and can improve heart recovery after the cardioplegic arrest.
G Calza; F Lerzo; F Perfumo; I Borini; G Panizzon; R Moretti; P Grasso; A Virgone; L Zannini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  43     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-18     Completed Date:  2002-10-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  IM    
Department of Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa, Italy.
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MeSH Terms
Cardiopulmonary Bypass
Case-Control Studies
Glutathione / metabolism
Myocardial Reperfusion
Myocardial Reperfusion Injury / diagnosis*
Myocardium / metabolism,  pathology*
Oxidative Stress*
Respiration, Artificial
Taurine / metabolism
Time Factors
Reg. No./Substance:
107-35-7/Taurine; 70-18-8/Glutathione

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