| Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. | |
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MedLine Citation:
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PMID: 12131781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Cholecystokinin (CCK)-receptor antagonists have been found to markedly reduce the severity of pancreatitis and improve survival in experimental animal models of acute pancreatitis. CCK appears to play an important role in the development and progression of acute pancreatitis, and the recent development of CCK antagonists has provided a new approach to the treatment of acute pancreatitis in humans. AIMS: The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated. METHODOLOGY: A multicenter dose-response controlled trial was conducted at 110 institutions in Japan from June 1993 to December 1994. Chronic pancreatitis was diagnosed for all patients on the basis of the Japanese criteria for chronic pancreatitis. Two-hundred seven patients were randomized to oral treatment with loxiglumide (300, 600, and 1,200 mg/d) or placebo for 4 weeks. The efficacy of treatment was evaluated on the basis of clinical symptoms, physical signs, and serum pancreatic enzyme levels. The groups were comparable with respect to age, sex, etiology, complications, and previous treatment. RESULTS: The improvement rate of the abdominal and/or back pain was 46% in the loxiglumide 300-mg group, 59% in the 600-mg group, and 52% in the 1,200-mg group, and it was 36% in the placebo group (600 mg versus placebo: p < 0.05). The physical signs evaluated--abdominal tenderness and resistance--improved in all three loxiglumide groups, and the serum pancreatic amylase and trypsin levels decreased significantly in the 600-mg group (p < 0.05). The overall clinical improvement rate was 46% in the 300-mg loxiglumide group, 58% in the 600-mg group, and 52% in the 1,200-mg group, and it was 34% in the placebo group. CONCLUSION: These results indicate that oral administration of loxiglumide may be useful in the treatment of patients with acute, painful attacks of chronic pancreatitis, and 600 mg/d is recommended as a beneficial dosage. |
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Authors:
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Keiko Shiratori; Tadashi Takeuchi; Katsusuke Satake; Seiki Matsuno; |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Pancreas Volume: 25 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2003-01-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: e1-5 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan. tskeiko@ige.tmmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Adult Amylases / blood Chronic Disease Female Hormone Antagonists / administration & dosage* Humans Lipase / blood Male Middle Aged Pain / etiology Pancreatitis / blood, complications, drug therapy* Proglumide / administration & dosage*, analogs & derivatives* Receptor, Cholecystokinin A Receptors, Cholecystokinin / antagonists & inhibitors Treatment Outcome Trypsin / blood |
| Chemical | |
Reg. No./Substance:
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0/Hormone Antagonists; 0/Receptor, Cholecystokinin A; 0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 6620-60-6/Proglumide; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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