Document Detail

Clinical evaluation of new antitumor antibiotics.
MedLine Citation:
PMID:  81505     Owner:  NLM     Status:  MEDLINE    
The clinical evaluation of new antibiotics and their analogs requires detailed analysis with respect to the best therapeutic strategy. In the case of anthracycline, diminished cardiac toxicity is as important an aim as increased activity. In the evaluation of cardiac toxicity the most important parameter must be the time to toxicity rather than the total dose. The new endomyocardial biopsy technique may be helpful in the study of analogs such as rubidazone, carminomycin and AD32. Actinomycin D analogs are also of interest, since this drug is part of several curative regimens, but its use has been limited by its severe acute toxicity. In the case of bleomycin, analogs with diminished pulmonary toxicity should be sought.
F M Muggia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  63     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  288-97     Citation Subset:  IM    
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MeSH Terms
Antibiotics, Antineoplastic / therapeutic use*
Bleomycin / analogs & derivatives,  therapeutic use
Dactinomycin / analogs & derivatives,  therapeutic use
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 11056-06-7/Bleomycin; 50-76-0/Dactinomycin

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