| Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. | |
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MedLine Citation:
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PMID: 21411411 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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UV is a major environmental factor inducing and worsening the symptoms of hyperpigmentation disorders such as freckles, melasma and solar lentigines. During UV-induced skin inflammatory reactions, pro-inflammatory mediators initiate the production of various paracrine melanogenic factors (α-MSH, SCF, ET-1, bFGF and NO) in keratinocytes. These paracrine factors activate melanin synthase in melanocytes through the paracrine network between melanocytes and keratinocytes. Glechoma hederacea (GH) is a herbal plant used in oriental medicine to treat inflammation. Its anti-inflammatory effects, through inhibition of NO synthesis (NOS) as well as the pro-inflammatory cytokine TNF-α, have been reported. However, there has not yet been any report of a depigmenting effect. In this study of placebo-controlled, 8 week topical treatment with a 1% GH extract lotion on UV-induced pigmented spots in female Asian subjects, significant effects of anti-inflammation and depigmenting were proven. The depigmenting effect of GH seems to be related to inhibiting the secretion of pro-inflammatory cytokines and melanogenic paracrine factors from keratinocytes, rather than to direct inhibition of melanogenic activities in melanocytes. |
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Authors:
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Jae Hyoun Ha; Won Hyung Kang; Jung Ok Lee; Youn Ki Cho; Sang Kyu Park; Sang Keun Lee; Han Kyoung Cho |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: - ISSN: 1167-1122 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Kwandong University College of Medicine, Myongji Hospital, Department of Dermatology, 697-24 Hwajeong-dong, Deokyang-gu, Goyang-city, Gyeonggi-do, Korea, 412-826Kwandong University College of Medicine, Myongji Hospital, Department of Dermatology, 697-24 Hwajeong-dong, Deokyang-gu, Goyang-city, Gyeonggi-do, Korea, 412-826. |
Vernacular Title:
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Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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