| Clinical evaluation of a citric acid inhaler for smoking cessation. | |
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MedLine Citation:
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PMID: 8436059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we evaluated the efficacy of a hand-held inhaler as an adjunct to a smoking cessation behavioral program. The inhaler delivered a citric acid aerosol with tobacco smoke flavor. Seventy-four smokers were recruited for a 3-week smoking cessation trial. During the first 12 days of the cessation period, smokers used the citric acid aerosol inhaler instead of a cigarette whenever the urge to smoke occurred. The citric acid inhaler significantly reduced CO levels and enhanced rates of smoking abstinence for those with higher than average (34.2 ppm) baseline end-expired carbon monoxide (CO) levels. Craving for cigarettes and negative affect were also alleviated by the citric acid aerosol. These results suggest that the citric acid aerosol may promote successful smoking reduction or cessation in a subgroup of smokers and relieves withdrawal symptoms such as craving for cigarettes, a symptom difficult to treat with currently available nicotine replacement techniques. |
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Authors:
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F M Behm; C Schur; E D Levin; D P Tashkin; J E Rose |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 31 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-24 Completed Date: 1993-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 131-8 Citation Subset: IM |
Affiliation:
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Duke University, Department of Psychiatry, Durham, North Carolina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols Affect / drug effects Behavior Therapy Breath Tests Carbon Monoxide / blood Citrates / administration & dosage* Citric Acid Double-Blind Method Equipment Design Female Humans Male Middle Aged Nebulizers and Vaporizers* Nicotine / adverse effects Smoking Cessation / methods* Substance Withdrawal Syndrome / blood, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Citrates; 54-11-5/Nicotine; 630-08-0/Carbon Monoxide; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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