Document Detail

Clinical evaluation of a citric acid inhaler for smoking cessation.
MedLine Citation:
PMID:  8436059     Owner:  NLM     Status:  MEDLINE    
In this study, we evaluated the efficacy of a hand-held inhaler as an adjunct to a smoking cessation behavioral program. The inhaler delivered a citric acid aerosol with tobacco smoke flavor. Seventy-four smokers were recruited for a 3-week smoking cessation trial. During the first 12 days of the cessation period, smokers used the citric acid aerosol inhaler instead of a cigarette whenever the urge to smoke occurred. The citric acid inhaler significantly reduced CO levels and enhanced rates of smoking abstinence for those with higher than average (34.2 ppm) baseline end-expired carbon monoxide (CO) levels. Craving for cigarettes and negative affect were also alleviated by the citric acid aerosol. These results suggest that the citric acid aerosol may promote successful smoking reduction or cessation in a subgroup of smokers and relieves withdrawal symptoms such as craving for cigarettes, a symptom difficult to treat with currently available nicotine replacement techniques.
F M Behm; C Schur; E D Levin; D P Tashkin; J E Rose
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  31     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-24     Completed Date:  1993-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
Duke University, Department of Psychiatry, Durham, North Carolina.
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MeSH Terms
Affect / drug effects
Behavior Therapy
Breath Tests
Carbon Monoxide / blood
Citrates / administration & dosage*
Citric Acid
Double-Blind Method
Equipment Design
Middle Aged
Nebulizers and Vaporizers*
Nicotine / adverse effects
Smoking Cessation / methods*
Substance Withdrawal Syndrome / blood,  prevention & control
Reg. No./Substance:
0/Aerosols; 0/Citrates; 54-11-5/Nicotine; 630-08-0/Carbon Monoxide; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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