Document Detail

Clinical evaluation of choline measurement by proton MR spectroscopy in patients with malignant tumors.
MedLine Citation:
PMID:  15287529     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine whether choline measurement by proton magnetic resonance (MR) spectroscopy in patients with malignant tumors is clinically meaningful in addition to routine MR imaging. MATERIALS AND METHODS: MR spectroscopy and MR imaging were performed in 27 consecutive patients with suspected malignant disease. Malignancy was assessed based on total choline compound levels using proton MR spectroscopy, and the results were compared with MR imaging findings. RESULTS: The sensitivity of MR imaging (84%, 21/25) was not significantly different from that of MR spectroscopy (88%, 22/25) among the 25 actual malignant diseases. Both MR imaging and MR spectroscopy produced two false-negative results. In one case, MR spectroscopy produced a false-negative result, whereas MR imaging produced a true-positive result. In two cases of benign breast disease, MR imaging produced false-positive results. MR spectroscopy produced one true-negative result and one false-positive result. CONCLUSION: Although choline measurement by MR spectroscopy is a useful tool in the evaluation of malignant disease, it should be reserved for patients with suspected malignant disease that cannot be detected by MR imaging, such as those with non-palpable prostate tumor with elevated sPSA levels.
Jin Lee; Takako Yamaguchi; Aya Abe; Kazuya Shizukuishi; Hiroji Uemura; Etsuko Miyagi; Katsumi Sakata; Tomio Inoue
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  22     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-08-03     Completed Date:  2004-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Department of Radiology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Aged, 80 and over
Brain Neoplasms / diagnosis*
Breast Neoplasms / diagnosis*
Choline / analysis*
Glioblastoma / diagnosis*
Magnetic Resonance Spectroscopy*
Middle Aged
Prostatic Neoplasms / diagnosis*
Sensitivity and Specificity
Uterine Neoplasms / diagnosis*
Reg. No./Substance:

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