| Clinical evaluation of the cardiac toxicity of 4'-deoxy-doxorubicin. | |
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MedLine Citation:
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PMID: 3403095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4'-deoxy-doxorubicin, a new doxorubicin analog, was tested in 65 phase II patients with advanced malignancies. Cardiac toxicity evaluation was performed by means of electrocardiography (ECG), left ventricular systolic time intervals, echocardiography and radionuclide left ventricular ejection fraction. ECG abnormalities were observed in a lower percentage of patients (23%) compared to that described for doxorubicin and other anthracycline analogs such as 4'-epi-doxorubicin and 4-demethoxy-daunorubicin. Other functional parameters serially measured to evaluate chronic cardiotoxicity in 23 patients, who received more than 200 mg/m2 were not significantly different from mean pretreatment values. No patient developed congestive heart failure but some of them exhibited a fall of left ventricular function parameters more than 15% from pretreatment values. These data suggest that this new analogue is probably less cardiotoxic than the parent compound doxorubicin but not completely devoid of cardiotoxicity. |
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Authors:
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F Villani; M Galimberti; R Comazzi; F Crippa; V Bonfante; L Ferrari; M A Pacciarini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology, therapy, and toxicology Volume: 26 ISSN: 0174-4879 ISO Abbreviation: Int J Clin Pharmacol Ther Toxicol Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-09-20 Completed Date: 1988-09-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003415 Medline TA: Int J Clin Pharmacol Ther Toxicol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 185-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Respiratory Physiopathology, National Institute for the Study and Therapy of Tumors, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibiotics, Antineoplastic / adverse effects* Doxorubicin / adverse effects, analogs & derivatives* Drug Evaluation Electrocardiography Female Heart Diseases / chemically induced*, physiopathology Hemodynamics / drug effects Humans Male Middle Aged Myocardial Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin; 63521-85-7/4'-deoxydoxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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