Document Detail


Clinical evaluation of the cardiac toxicity of 4'-deoxy-doxorubicin.
MedLine Citation:
PMID:  3403095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
4'-deoxy-doxorubicin, a new doxorubicin analog, was tested in 65 phase II patients with advanced malignancies. Cardiac toxicity evaluation was performed by means of electrocardiography (ECG), left ventricular systolic time intervals, echocardiography and radionuclide left ventricular ejection fraction. ECG abnormalities were observed in a lower percentage of patients (23%) compared to that described for doxorubicin and other anthracycline analogs such as 4'-epi-doxorubicin and 4-demethoxy-daunorubicin. Other functional parameters serially measured to evaluate chronic cardiotoxicity in 23 patients, who received more than 200 mg/m2 were not significantly different from mean pretreatment values. No patient developed congestive heart failure but some of them exhibited a fall of left ventricular function parameters more than 15% from pretreatment values. These data suggest that this new analogue is probably less cardiotoxic than the parent compound doxorubicin but not completely devoid of cardiotoxicity.
Authors:
F Villani; M Galimberti; R Comazzi; F Crippa; V Bonfante; L Ferrari; M A Pacciarini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  26     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-09-20     Completed Date:  1988-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Affiliation:
Department of Cardiology and Respiratory Physiopathology, National Institute for the Study and Therapy of Tumors, Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibiotics, Antineoplastic / adverse effects*
Doxorubicin / adverse effects,  analogs & derivatives*
Drug Evaluation
Electrocardiography
Female
Heart Diseases / chemically induced*,  physiopathology
Hemodynamics / drug effects
Humans
Male
Middle Aged
Myocardial Contraction / drug effects
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin; 63521-85-7/4'-deoxydoxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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