Document Detail


Clinical evaluation of angiotensin II enhanced perfusion scintigraphy in metastatic liver disease.
MedLine Citation:
PMID:  2812638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hepatic perfusion index (HPI) may be of value in the diagnosis of liver micro-metastases. However, raised values of HPI also occur in some benign liver conditions (e.g. cirrhosis), thereby weakening the diagnostic power of this test. It has been suggested that infusion of the vaso-active agent angiotensin II might improve the predictive value of dynamic scintigraphy because it has been shown to alter liver perfusion in patients with metastatic liver disease. Basal HPI values were not significantly different in a group of patients with metastases (n = 10) and a group with cirrhosis (n = 9). A significant rise in HPI occurred in the metastatic group using angiotensin II enhancement (p less than 0.01, Wilcoxon test). In the cirrhotic group there was no significant increase in the HPI with angiotensin II enhancement. Within the groups, there was considerable variation in response, with eight of ten metastatic and five of nine cirrhotic patients showing a rise in HPI during an angiotensin II infusion. As a result, there was complete overlap in the angiotensin II enhanced HPI for the two groups. Angiotensin II enhancement of HPI is therefore unlikely to improve the diagnostic power of dynamic scintigraphy in individual patients with established hepatic disease.
Authors:
J A Goldberg; J Fenner; R G Bessent; M S Bradnam; J H McKillop; R F McKee; C S McArdle; D J Kerr
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  10     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-66     Citation Subset:  IM    
Affiliation:
University Department of Surgery, Royal Infirmary, Glasgow, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / diagnostic use*
Diagnosis, Differential
Evaluation Studies as Topic
Gastrointestinal Neoplasms
Humans
Liver Cirrhosis / radionuclide imaging
Liver Cirrhosis, Biliary / radionuclide imaging
Liver Function Tests / methods*
Liver Neoplasms / blood supply,  radionuclide imaging,  secondary*
Perfusion
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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