| Clinical evaluation of SMS 201-995. Long-term treatment in gut neuroendocrine tumours, efficacy of oral administration, and possible use in non-tumoural inappropriate TSH hypersecretion. | |
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MedLine Citation:
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PMID: 2892335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-acting somatostatin analogues such as SMS 201-995 (Sandoz) are being evaluated in a wide range of clinical indications, including gut neuroendocrine tumours and acrogemaly. Long-term continuous SMS 201-995 treatment has achieved useful symptomatic improvement in diarrhoea in 4 patients with metastatic VIPomas who had relapsed following previous treatment. Clinical improvement has outlasted suppression of VIP secretion (suggesting an additional direct antisecretory action of SMS 201-995) and has occurred despite expansion of hepatic metastases. In 6 patients with tumours secreting gastrin and/or glucagon, secretion of these peptides was acutely inhibited by SMS 201-995. However, endocrine and clinical responses to chronic treatment have been less consistent. SMS 201-995 is active orally at doses of 4-8 mg and when given thrice-daily to 6 patients with active acromegaly, suppressed mean 24-h growth hormone levels by 51-88%. Despite significantly reduced plasma insulin concentrations, glucose tolerance did not deteriorate. SMS 201-995 was also effective in suppressing thyroid-stimulating hormone (TSH) and thyroid hormone secretion in a patient with mild thyrotoxicosis due to non-tumoural inappropriate TSH hypersecretion. In all cases SMS 201-995 treatment has been well tolerated and has few side-effects. |
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Authors:
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G Williams; J V Anderson; S J Williams; S R Bloom |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta endocrinologica. Supplementum Volume: 286 ISSN: 0300-9750 ISO Abbreviation: Acta Endocrinol Suppl (Copenh) Publication Date: 1987 |
Date Detail:
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Created Date: 1988-02-17 Completed Date: 1988-02-17 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 0370313 Medline TA: Acta Endocrinol Suppl (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 26-36 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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blood,
drug therapy Adenoma / secretion Adult Aged Diarrhea / drug therapy Female Gastrointestinal Neoplasms / drug therapy* Glucagonoma / blood, drug therapy Growth Hormone / blood Humans Hyperthyroidism / drug therapy, etiology Liver Neoplasms / drug therapy, pathology, secondary Male Middle Aged Neoplasms, Glandular and Epithelial / drug therapy* Octreotide Pancreatic Neoplasms / blood, drug therapy*, pathology Pituitary Neoplasms / secretion Somatostatin / adverse effects, analogs & derivatives*, therapeutic use Streptozocin / therapeutic use Thyrotropin / secretion* Vasoactive Intestinal Peptide / blood Vipoma / blood, drug therapy, pathology Zollinger-Ellison Syndrome / blood, drug therapy |
| Chemical | |
Reg. No./Substance:
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18883-66-4/Streptozocin; 37221-79-7/Vasoactive Intestinal Peptide; 51110-01-1/Somatostatin; 83150-76-9/Octreotide; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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