| Clinical evaluation of PMX-DHP for hypercytokinemia caused by septic multiple organ failure. | |
| | |
MedLine Citation:
|
PMID: 15274680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endotoxin-adsorbing fibers have been applied to treat septic shock patients. The limitations of endotoxin hemoadsorption therapy (PMX-DHP) and the optimal time to start PMX-DHP were examined in patients with septic multiple organ failure with hypercytokinemia (interleukin-6 = 1000 pg/mL). Subjects were separated into those who survived more than 28 days after the start of PMX-DHP therapy (S group) and those who did not (N-S group). Severity of symptoms and background factors, blood biochemical parameters, hemodynamic parameters, PaO(2)/FiO(2), pathogens, endotoxin, cytokines, and vascular endothelial cell function-related markers were examined before and after PMX-DHP. Number of days from onset of shock (or symptom development) to PMX-DHP initiation was longer in the N-S group than in the S group. These results suggest that PMX-DHP could save more lives in patients with septic multiple organ failure with IL-6 = 1000 pg/mL when applied early after the onset of shock. |
| | |
Authors:
|
Toshiaki Ikeda; Kazumi Ikeda; Masatoshi Nagura; Hitoshi Taniuchi; Mikiko Matsushita; Shintarou Kiuchi; Yuichi Kuroki; Kaori Suzuki; Naoto Matsuno |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 8 ISSN: 1744-9979 ISO Abbreviation: Ther Apher Dial Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-07-27 Completed Date: 2004-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: United States |
Other Details:
|
Languages: eng Pagination: 293-8 Citation Subset: IM |
Affiliation:
|
Division of Critical Care and Emergency Medicine, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan. toshi@tokyo-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
APACHE Anti-Bacterial Agents E-Selectin / blood Endotoxins / blood Hemoperfusion Humans Intercellular Adhesion Molecule-1 / blood Interleukin-6 / blood* Multiple Organ Failure / complications, therapy* Polymyxin B Shock, Hemorrhagic / therapy* Systemic Inflammatory Response Syndrome / therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/E-Selectin; 0/Endotoxins; 0/Interleukin-6; 126547-89-5/Intercellular Adhesion Molecule-1; 1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymyxin B-immobilized fiber hemoperfusion after emergency surgery in patients with chronic renal f...
Next Document: Effect of post-transplant double filtration plasmapheresis on recurrent focal and segmental glomerul...