| Clinical evaluation of the NBD-PC fluorescence polarization assay for prediction of fetal lung maturity. | |
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MedLine Citation:
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PMID: 1407896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: 1) To examine a fluorescence polarization (FP) assay with an independent set of data that contained more cases of respiratory distress syndrome (RDS) than a previous study, 2) to determine whether the same reference ranges are applicable to infants born to diabetic women, and 3) to evaluate whether adding the lecithin-sphingomyelin ratio (L/S) would substantially improve the prediction of RDS among women with an intermediate FP value (between 0.26-0.289). METHODS: We identified 389 women who had FP analysis performed at the University of Washington Medical Center from February 1986 to October 1988 and who delivered within 3 days of amniocentesis. We reviewed the medical records of these women and their infants to extract information for our study. RESULTS: For FP values of 0.26 or greater, the sensitivity and specificity for prediction of RDS were 90.2 and 84.6%, respectively, compared with 100 and 82.0% in the previous study. For FP values of 0.29 or greater, the sensitivity and specificity were 62.8 and 94.2%, respectively (80.8 and 96.2% in the previous study). Among diabetics, an FP result below 0.26 was associated with the same low risk of RDS as among non-diabetics. Among the patients with FP between 0.26-0.289, the addition of L/S did not provide a clinically useful improvement in the prediction of fetal lung maturity. CONCLUSION: The NBD-PC FP assay can be used as the sole test of fetal lung maturity in most clinical circumstances. |
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Authors:
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C Chen; P V Roby; N S Weiss; J A Wilson; T J Benedetti; J F Tait |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 80 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-26 Completed Date: 1992-10-26 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 688-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Laboratory Medicine, University of Washington, Seattle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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chemistry* Evaluation Studies as Topic Female Fetal Organ Maturity* Fluorescence Polarization* / methods Gestational Age Humans Infant, Newborn Lung / embryology* Phosphatidylcholines / analysis, diagnostic use* Phospholipids / analysis Predictive Value of Tests Pregnancy Pregnancy in Diabetics Pulmonary Surfactants / analysis* Reference Values Respiratory Distress Syndrome, Newborn / epidemiology Sensitivity and Specificity Sphingomyelins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Phospholipids; 0/Pulmonary Surfactants; 0/Sphingomyelins; 81005-34-7/1-palmitoyl-2-(6-(N-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine |
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