| Clinical evaluation of 99mTc diaminocyclohexane, a renal tubular agent with cationic transport: results in healthy human volunteers. | |
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MedLine Citation:
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PMID: 8247196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As alternatives to anionically transported hippuran, structure distribution experiments on a series of 99mTc-labelled primary substituted ethylene diamine compounds led to selection of 99mTc diaminocyclohexane (DACH) for clinical evaluation, 99mTc DACH, a cation with the structure trans-[O2(DACH)2 99mTc]+ is prepared by mixing 50 mumol DACH, 1 mumol stannous tartrate and 500 MBq of 99mTc. Seven normal volunteers underwent renal imaging and clearance studies using 150 MBq of 99mTc DACH and 1 MBq of 125I hippuran simultaneously. The images with 99mTc DACH revealed good uptake and excretion. The mean +/- 2 SD values of parenchymal and whole-kidney transit time indices and mean parenchymal transit time were 46 +/- 33, 75 +/- 64 and 141 +/- 51 s, respectively, similar to mercaptoacetyl triglycine. The mean clearance of 99mTc DACH was found to be 163 ml/min (SD = 32). Following cationic blockade with 900 mg oral thiamine, significant reduction (p < 0.001) in DACH clearance was noted, but hippuran clearance remained unaltered. The results support the hypothesis that 99mTc DACH is transported cationically. |
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Authors:
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A K Padhy; K K Solanki; J Bomanji; T Chaiwatanarat; C C Nimmon; K E Britton |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nephron Volume: 65 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1993 |
Date Detail:
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Created Date: 1994-01-05 Completed Date: 1994-01-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 294-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, St. Bartholomew's Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Transport / drug effects Cations / pharmacokinetics Cyclohexylamines* Glomerular Filtration Rate Humans Iodohippuric Acid / diagnostic use, pharmacokinetics Kidney / metabolism, radionuclide imaging Kidney Tubules / metabolism*, radionuclide imaging* Male Middle Aged Organotechnetium Compounds / diagnostic use*, pharmacokinetics*, urine Thiamine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/Cyclohexylamines; 0/Organotechnetium Compounds; 0/technetium Tc 99m diaminocyclohexane; 147-58-0/Iodohippuric Acid; 59-43-8/Thiamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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