Document Detail

Clinical evaluation of 99mTc diaminocyclohexane, a renal tubular agent with cationic transport: results in healthy human volunteers.
MedLine Citation:
PMID:  8247196     Owner:  NLM     Status:  MEDLINE    
As alternatives to anionically transported hippuran, structure distribution experiments on a series of 99mTc-labelled primary substituted ethylene diamine compounds led to selection of 99mTc diaminocyclohexane (DACH) for clinical evaluation, 99mTc DACH, a cation with the structure trans-[O2(DACH)2 99mTc]+ is prepared by mixing 50 mumol DACH, 1 mumol stannous tartrate and 500 MBq of 99mTc. Seven normal volunteers underwent renal imaging and clearance studies using 150 MBq of 99mTc DACH and 1 MBq of 125I hippuran simultaneously. The images with 99mTc DACH revealed good uptake and excretion. The mean +/- 2 SD values of parenchymal and whole-kidney transit time indices and mean parenchymal transit time were 46 +/- 33, 75 +/- 64 and 141 +/- 51 s, respectively, similar to mercaptoacetyl triglycine. The mean clearance of 99mTc DACH was found to be 163 ml/min (SD = 32). Following cationic blockade with 900 mg oral thiamine, significant reduction (p < 0.001) in DACH clearance was noted, but hippuran clearance remained unaltered. The results support the hypothesis that 99mTc DACH is transported cationically.
A K Padhy; K K Solanki; J Bomanji; T Chaiwatanarat; C C Nimmon; K E Britton
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  65     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-05     Completed Date:  1994-01-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  IM    
Department of Nuclear Medicine, St. Bartholomew's Hospital, London, UK.
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MeSH Terms
Biological Transport / drug effects
Cations / pharmacokinetics
Glomerular Filtration Rate
Iodohippuric Acid / diagnostic use,  pharmacokinetics
Kidney / metabolism,  radionuclide imaging
Kidney Tubules / metabolism*,  radionuclide imaging*
Middle Aged
Organotechnetium Compounds / diagnostic use*,  pharmacokinetics*,  urine
Thiamine / pharmacology
Reg. No./Substance:
0/Cations; 0/Cyclohexylamines; 0/Organotechnetium Compounds; 0/technetium Tc 99m diaminocyclohexane; 147-58-0/Iodohippuric Acid; 59-43-8/Thiamine

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