Document Detail

Clinical, etiological and progression factors of hearing in sudden deafness.
MedLine Citation:
PMID:  16612525     Owner:  NLM     Status:  MEDLINE    
Out of the many forms of therapy for sudden deafness, some require hospitalization and present significant risks. AIM: This prospective study analyzes etiology and evolution in cases of sudden deafness (SD) where outpatient oral treatment was used. STUDY DESIGN: Clinical with transversal cohort. MATERIAL AND METHOD: Forty cases of sudden hearing loss were followed for at least one year. All were submitted to initial clinical evaluation, auditory tests, routine blood analysis, and magnetic resonance imaging. All received initial treatment with pentoxifylline and prednisone. RESULTS: 45% (n=18) presented normal auditory thresholds, 40% (n=16) showed some improvement in hearing, 15% (n=6) maintained initial hearing level. Nine cases (22.5%) presented clinical conditions possibly implicated in hearing loss (viral infection, immunomediated hearing loss, vascular disorders, and so on); three (7.5%) had cerebellopontine tumors. Evolution of hearing in these 12 cases with presumed etiology presented no differences from hearing in the 28 cases without any known etiological factor. Clinical treatment within the first seven days was the only statistically significantly different condition in patients who improved hearing. CONCLUSIONS: An objective search for etiological bases should be conducted in any case of acute sensorineural hearing loss. The presence of cerebellopontine tumors in 7.5% of cases of SD, among other treated causes, justifies a thorough clinical investigation in these patients. Overall good evolution of hearing was observed in 67.5% of cases of SD, regardless of its etiology. Therapy within the first seven days of SD was significantly related to better outcomes in hearing.
Norma de Oliveira Penido; Hugo Valter Lisboa Ramos; Flávia Alencar Barros; Oswaldo Laércio Mendonça Cruz; Ronaldo Nunes Toledo
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Publication Detail:
Type:  Journal Article     Date:  2006-03-31
Journal Detail:
Title:  Brazilian journal of otorhinolaryngology     Volume:  71     ISSN:  1808-8694     ISO Abbreviation:  -     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2006-04-13     Completed Date:  2006-08-21     Revised Date:  2008-10-06    
Medline Journal Info:
Nlm Unique ID:  101207337     Medline TA:  Braz J Otorhinolaryngol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  633-8     Citation Subset:  IM    
Federal University of Sao Paulo, Escola Paulista de Medicina.
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MeSH Terms
Auditory Threshold / physiology
Cross-Sectional Studies
Disease Progression
Follow-Up Studies
Glucocorticoids / therapeutic use
Hearing Loss, Sudden / drug therapy,  etiology*
Middle Aged
Pentoxifylline / therapeutic use
Prednisone / therapeutic use
Prospective Studies
Treatment Outcome
Vasodilator Agents / therapeutic use,  urine
Reg. No./Substance:
0/Glucocorticoids; 0/Vasodilator Agents; 53-03-2/Prednisone; 6493-05-6/Pentoxifylline

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