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Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case-series study.
MedLine Citation:
PMID:  23301847     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The International Psoriasis Council in 2007 considered palmoplantar pustulosis (PPP) as a separate condition from psoriasis, despite the presence of certain phenotypes common in both diseases. OBJECTIVE: To describe and compare demographic and clinical characteristics among PPP and palmoplantar plaque psoriasis. METHODS: Retrospective case-series study from 2005 to 2010. The following data were obtained: age, sex, family history, smoking habits, nail involvement, joint involvement, disease duration, lesions morphology (plaque or pustular), histological diagnosis, co-morbidities, and PGA score for extra-palmoplantar lesions. Sample size calculation indicated that 80 patients, 40 patients for each group (palmoplantar plaque psoriasis and PPP) were needed to see clinically relevant differences between groups. RESULTS: Ninety patients were selected: 51 had palmoplantar plaque psoriasis and 39 had PPP. No statistically significant differences were registered between patients affected by PPP and palmoplantar plaque psoriasis as regards age at the onset of the disease (48 vs. 44 years; p 0.4), disease duration (6 vs. 10 years; p 0.1), family history of psoriasis (28.2% vs. 33.3%; p 0.7), concomitant arthritis (25.6% vs. 25.5%; p 1.0), or smoking habits (54.1% vs. 41.2%; p 0.2). We observed a female predominance (p 0.01) and a lesser frequency of nail involvement (p 0.03) in patients affected by PPP. CONCLUSIONS: Our data suggest a close relationship between PPP and psoriasis. The existing data concerning epidemiology, clinical presentation, genetics, histopathology and pathogenesis do not permit a clear distinction between these two entities, which seem to coincide in many aspects. PPP appears to have a marked predilection among female smokers.
Authors:
A M G Brunasso; M Puntoni; W Aberer; C Delfino; L Fancelli; C Massone
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©The Authors bjd © 2013 British Association of Dermatologists.
Affiliation:
Department of Environmental Dermatology and Venereology, Medical University of Graz, Graz, Austria; Department of Dermatology, Galliera Hospital, Genoa, Italy.
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