| Clinical electrophysiology and visual outcome in optic nerve hypoplasia. | |
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MedLine Citation:
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PMID: 19955198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: In optic nerve hypoplasia (ONH), the extent of functional loss of retinal ganglion cells cannot be determined by ophthalmoscopic examination. The prognostic value of visual electrodiagnostic tests in infants and toddlers with ONH was assessed by comparison with visual outcome. METHODS: 85 participants with ONH had electroretinogram (ERG) and visual-evoked potential (VEP) testing to flash and to pattern-reversal checks and ocular fundus photography prior to 36 months of age. These initial measures were compared with visual acuity outcomes at 5 years of age in the better-seeing eye. RESULTS: Visual outcomes ranged from normal to no light perception. Electrodiagnostic tests with prognostic value were: the amplitude of the flash VEP (Spearman's rank correlations, p<0.001), the threshold category of stimulus (flash or check size) that elicited a VEP (p<0.001) and the amplitude of the N95 component of the pattern ERG (PERG) to 4-degree checks (p<0.02). Optic nerve size and co-existing pallor were also significant correlates. Stepwise regression analysis composed a best prediction model from VEP threshold category, optic nerve size and optic disc pallor (R(2)=58%; p<0.001). CONCLUSIONS: Optic disc diameter, observation of disc pallor, VEP and PERG testing in infancy are useful for establishing the visual prognosis at 5 years of age in children with ONH. This is consistent with the notion that these parameters are related to the anatomic and functional preservation of retinal ganglion cells. |
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Authors:
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D L McCulloch; P Garcia-Filion; C Fink; C A Chaplin; M S Borchert |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-12-02 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 94 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 1017-23 Citation Subset: IM |
Affiliation:
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Vision Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA, UK. dlmc@gcal.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Child, Preschool Electroretinography / methods Epidemiologic Methods Evoked Potentials, Visual / physiology Female Humans Infant Male Optic Disk / pathology Optic Nerve / abnormalities*, pathology Prognosis Retinal Ganglion Cells / physiology Signal Processing, Computer-Assisted Vision Disorders / etiology*, pathology, physiopathology Visual Acuity / physiology |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00043/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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