Document Detail

Clinical and electrophysiological study of intermediate syndrome in patients with organophosphorous poisoning.
MedLine Citation:
PMID:  7852225     Owner:  NLM     Status:  MEDLINE    
Intermediate syndrome (IS) developed in 38 of 214 cases with organophosphorous compound poisoning (OPCP). Neck muscle weakness, motor cranial nerve palsy, respiratory muscle paralysis, proximal limb weakness were the chief neurological signs developed 16-120 hours after consumption of the insecticide. Two patients had pyramidal tract signs. Mean duration of IS was 9.26 (+/- 4.84) days. Electrophysiological study (EPS) was done in 21 patients. 18 patients showed decremental response to repetitive stimulation at 3Hz 5 pulses and absence of post tetanic facilitation. Motor conduction studies were abnormal in on (prolonged distal latency and reduced conduction velocity), 'F' responses were abnormal in, sensory nerve conduction was abnormal in two, and simple repetitive response were observed in 11 patients. 4 patients died. In IS neuromuscular junctional dysfunction is the predominant factor.
K K Shailesh; P Pais; B Vengamma; U Muthane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  42     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-03-15     Completed Date:  1995-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  451-3     Citation Subset:  IM    
St. John's Medical College Hospital, Bangalore.
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MeSH Terms
Critical Care
Middle Aged
Neuromuscular Junction / drug effects,  physiopathology
Organophosphorus Compounds / poisoning*
Paralysis / chemically induced*,  mortality,  physiopathology
Prospective Studies
Reaction Time / drug effects,  physiology
Synaptic Transmission / drug effects*,  physiology
Reg. No./Substance:
0/Organophosphorus Compounds

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